Phenylketonuria (PKU) is a disorder caused by a defect in the gene that codes for the phenylalanine hydroxylase (PAH), an enzyme required to break down the amino acid phenylalanine. The results of a newborn screening test indicated that Jack and Jill’s baby has phenylketonuria (PKU). Neither Jack nor Jill has PKU. A DNA test indicated that there was no switching of babies - Jack and Jill are the baby's real parents. How is this possible? A. Jack and Jill are both heterozygous for the gene that codes for PAH. B. Jack and Jill are both homozygous for the normal allele that codes for PAH. C. One parent is heterozygous for the gene for PAH, the other parent is homozygous for the normal allele. D. One parent is heterozygous for the gene for PAH, the other parent is homozygous for the defective allele.

Phenylketonuria (PKU) is a disorder caused by a defect in the gene that codes for the phenylalanine hydroxylase (PAH), an enzyme required to break down the amino acid phenylalanine. The results of a newborn screening test indicated that Jack and Jill’s baby has phenylketonuria (PKU). Neither Jack nor Jill has PKU. A DNA test indicated that there was no switching of babies - Jack and Jill are the baby's real parents. How is this possible? A. Jack and Jill are both heterozygous for the gene that codes for PAH. B. Jack and Jill are both homozygous for the normal allele that codes for PAH. C. One parent is heterozygous for the gene for PAH, the other parent is homozygous for the normal allele. D. One parent is heterozygous for the gene for PAH, the other parent is homozygous for the defective allele.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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Phenylketonuria and alkaptonuria are both autosomal recessive diseases. If a person with PKU marries a person with AKU, what will the phenotype of their children be?
a. If an individual who is homozygous for the mutation found in individual 2 and heterozygous for the mutation found in individual 4 marries an individual who is homozygous for the mutation found in individual 4 and heterozygous for the mutation found in individual 2, what will be the phenotype of their children? b. List the intermediate that would build up in each of the types of children who could not produce protein E.
Phenylketonuria (PKU) is a disorder caused by a defect in the gene that codes for the phenylalanine hydroxylase (PAH), an enzyme required to break down the amino acid phenylalanine. The results of a newborn screening test indicated that Jack and Jill’s baby has phenylketonuria (PKU). Neither Jack nor Jill has PKU. A DNA test indicated that there was no switching of babies - Jack and Jill are the baby's real parents. What is the probability that their next child will have PKU?
Phenylketonuria (PKU) is a disorder caused by a defect in the gene that codes for the phenylalanine hydroxylase (PAH), an enzyme required to break down the amino acid phenylalanine. The results of a newborn screening test indicated that Jack and Jill’s baby has phenylketonuria (PKU). Neither Jack nor Jill has PKU. A DNA test indicated that there was no switching of babies - Jack and Jill are the baby's real parents. What is the probability that their next child will have PKU? Answer in fraction:
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Phenylketonuria (PKU) is a human hereditary disease resulting from the inability of the body to process the chemical phenylalanine, which is contained in the protein we eat. PKU is manifest in early infancy and, if it remains untreated, generally leads to cognitive impairment. PKU is caused by a recessive allele with simple Mendelian inheritance. A couple intends to have children but consults a genetic counselor because the man has a sister with PKU and the woman has a brother with PKU. There are no other known cases in their families. They ask the genetic counselor to determine the probability that their first child will have PKU. What is this probability?
Phenylketonuria (PKU) is an autosomal recessive disease that results from a defect in an enzyme that normally metabolizes the amino acid phenylalanine; when this enzyme is defective, high levels of phenylalanine cause brain damage. In the past, most children with PKU became intellectually disabled. Fortunately, intellectual disability can be prevented in these children by carefully controlling the amount of phenylalanine in the diet. The diet is usually applied during childhood, when brain development is taking place. As a result of this treatment, many people with PKU now reach reproductive age. Children born to women with PKU (who are no longer on a phenylalanine-restricted diet) frequently have low birth weight, developmental abnormalities, and intellectual disabilities. However, children of men with PKU do not have these problems. a. Provide an explanation for these observations. b. What type of genetic effect is this? Explain your reasoning.
Phenylketonuria (PKU) is an autosomal recessive disease that results from a defect in an enzyme that normally metabolizes the amino acid phenylalanine; when this enzyme is defective, high levels of phenylalanine cause brain damage, in the past, most children with PKU became intellectually disabled. Fortunately, intellectual disability can be prevented in these children by carefully controlling the amount of phenylalanine in the diet. The diet is usually applied during childhood when the brain development is taking place. As a result of this treatment, many people with PKU now reach reproductive age. Children born to women with PKU (who are no longer on a phenylalanine-restricted diet) frequently have low birth weight, developmental abnormalities, and intellectual disabilities. However, children of men with PKU do not have these problems. QUESTION: Describe the results depicted in Fig. 1 Use the first question to provide an explanation for these observations. What type of genetic…
Phenylketonuria (PKU) is an autosomal recessive disease that results from a defect in an enzyme that normally metabolizes the amino acid phenylalanine; when this enzyme is defective, high levels of phenylalanine cause brain damage. In the past, most children with PKU became intellectually disabled. Fortunately, intellectual disability can be prevented in these children by carefully controlling the amount of phenylalanine in the diet. The diet is usually applied during childhood, when brain development is taking place. As a result of this treatment, many people with PKU now reach reproductive age. Children born to women with PKU (who are no longer on a phenylalanine-restricted diet) frequently have low birth weight, developmental abnormalities, and intellectual disabilities. However, children of men with PKU do not have these problems. Q. Provide an explanation for these observations.
Phenylketonuria (PKU) is an autosomal recessive disease that results from a defect in an enzyme that normally metabolizes the amino acid phenylalanine; when this enzyme is defective, high levels of phenylalanine cause brain damage, in the past, most children with PKU became intellectually disabled. Fortunately, intellectual disability can be prevented in these children by carefully controlling the amount of phenylalanine in the diet. The diet is usually applied during childhood when the brain development is taking place. As a result of this treatment, many people with PKU now reach reproductive age. Children born to women with PKU (who are no longer on a phenylalanine-restricted diet) frequently have low birth weight, developmental abnormalities, and intellectual disabilities. However, children of men with PKU do not have these problems. Describe the results depicted in Fg1. and us it to provide an explanation for these observations What type of genetic effect is…
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