Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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The following pedigree shows the inheritance of Huntington’s disease, a fatal genetic disorder that causes neurodegeneration. Since signs and symptoms usually do not appear until adulthood, many who are carriers may not realize their risk of passing on the disease-causing allele. The following pedigree represents a family in which some people are affected by Huntington’s disease.
- Using just the information on this pedigree, is Huntington’s disease caused by a dominant allele or recessive alleles?
- What are the genotypes of the grandparents (I-1 and I-2)?
- What are the genotypes of the parents (II-6 and II-7)?
- If the parents above have another child, what is the chance that they will be affected by the Hungtington’s disease allele?
- What are the genotypes of the unaffected children (III-8, 9, 10)?
- What is the chance that the unaffected children above will pass on a Huntington’s disease allele to their children?
- What is the genotype of the affected child (III-11)?
- What is the chance that the affected child above will pass on the Huntington’s disease allele to a child?
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