Name a nucleoside analog. Explain how that nucleoside analog works. Which viruses are effectively treated by that nucleoside analog?

Why are structural analogs of sugar molecules (such as Oseltamivir and zanamivir) effective in treatment of influenza-virus infection?

True or False. 1. a.) RNA polymerase decodes mRNA so the ribosome can make proteins. b.) Only coding RNA can interact with the ribosome. c.) The ribosome is composed of both protein and ncRNA. d.)The ncRNA components of the ribosome behave as a ribozyme. Pick one of the FALSE statements from the 4 previous questions and explain why it is incorrect.

Give an example of a nucleoside analogue that has been used successfully as an antiretroviral drug. How does it work thanks

Given this viral mRNA, which model represents the correct (+)ssRNA genome from which it was made? mRNA AUAUUUGCG... O O (+) AUAUUUGCG. (+) UAUAAACGC_ (+) AUAUUUGCG. (+) UAUAAACGC

Several common antibiotics affect some strains of bacteria's ability to carry out transcription and/or translation.  For example: Rifamycin inhibits prokaryotic RNA polymerase Chloramphenicol blocks the transfer of the peptide from the P to A site. a) For each of these drugs, identify at what point it could affect the process of DNA->RNA->protein. Be as specific as possible. b) Why do you think these drugs kill bacteria but spare animal cells? (Hint: remember bacteria are prokaryotes)

Can you please help me by drawing a serie of schematic figures that demonstrates the information in the paragraph below. The carboxy terminus of the p53 protein acts as an allosteric regulator of sequence-specific DNA binding. This was demonstrated initially by Hupp et al. (1992) using a bacterially expressed protein. Recombinant bacterial p53 bound poorly to DNA, and binding could be enhanced by the addition of antibodies specific to the C-terminal region of the protein. Phosphorylation of Ser315 and Ser392 within this domain also enhance sequence-specific DNA binding. Dephosphorylation of Ser376 of p53 after IR allows the association of 14-3-3 proteins with the C terminus of the protein (Waterman et al., 1998). Stavridi et al. (2001) demonstrate that this interaction is required for p53 to activate the downstream gene, p21waf1/cip1, and for the G1 cell cycle checkpoint arrest response. Interestingly, this dephosphorylation event seems to be ATM-dependent, possibly by a phosphatase…

In principle, RNAi may be used to fight viral infection. How might this work?

Match the following antibiotics with the drug strategy that would provide resistance to them. rifampin which blocks transcription [ Choose ] Choose] tetracycline which misaligns the beta-lactamase anticodon to its codon mutation of the TRNA binding site of the ribosome penicillin which blocks peptidoglycan creation of alternate metabolic pathway that ultimately leads to the same product synthesis mutation of RNA polymerase polymyxin which causes leakage in the porin which removes drug from periplasmic space cell membrane sulfonamide which inhibits enzyme of [Choose ] folic acid synthesis pathway Question 14 2 pts % & 5 7

The genome of SARS-CoV-2 is a single-stranded sense (coding) mRNA that is translated into many functional and structural proteins required for the replication and assembly of the virus, including the famous spike protein. Comparing the sequence to that of SARS-CoV-1 and a number of other beta-coronaviruses reveals that by far the most conserved sequence within the entire ~30,000 nucleotide mRNA genome is located in the 3'-UTR, near the end of the message. The difference between that sequence in the original isolates of SARS-CoV-2 is only 1 in 50 nucleotides. What is the most likely explanation for this high degree of sequence conservation? The mRNA in this region encodes for a protein with a required proteus site to make the mature viral coat protein that participates in membrane fusion, without which the virus cannot propagate. The mRNA in this region encodes for an essential protein whose fold cannot tolerate amino acid substitutions. The mRNA in this region is part of a required…