Macmillan Learning What factors promote the fidelity of replication during synthesis of the leading strand of DNA? removal of the RNA primers between Okazaki fragments by DNA polymerase I breaks that occur in the leading strand are repaired by DNA ligase prevention of mismatched nucleotides at the replication fork by topoisomerase removal of wrongly inserted nucleotides by the 3'-exonuclease activity of DNA polymerase III Watson-Crick base pairing between the template and leading strand

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Which statements are true? Explain why or why not.1 The different cells in your body rarely havegenomes with the identical nucleotide sequence.2 In E. coli, where the replication fork travels at 500nucleotide pairs per second, the DNA ahead of the fork—in the absence of topoisomerase—would have to rotate atnearly 3000 revolutions per minute.3 In a replication bubble, the same parental DNAstrand serves as the template strand for leading-strandsynthesis in one replication fork and as the template forlagging-strand synthesis in the other fork.4 When bidirectional replication forks from adja-cent origins meet, a leading strand always runs into a lag-ging strand.5 DNA repair mechanisms all depend on the exis-tence of two copies of the genetic information, one in eachof the two homologous chromosomes

Exercise 15. What is the resulting amino acid sequence from the parent DNA double helix as follows? - 5' 3' - AAG ACC CT T T 5'- TT CT G G G A A A A ACT A AGT T GA T T C A - 3' b. If the C at the 5th DNA base (3'5' strand) was deleted, what is mutated mRNA and the resulting amino acid sequence? TA

How does DNA replicate itself? Your explanation (in essay form) should include the following terms: helicase, origins of replication, primase, DNA polymerase (I, II and III), leading strand, lagging strand, Okazaki fragment, DNA ligase, and topoisomerase.

How would you calculate the amplicon in DNA!

DNA synthesis by DNA polymerases exemplitiės Q6 DNA synthesis Growing strand Template (primer) strand DNA polymerase G NH DNA primer Mg2+ NH2 Asp- Asp- 5' P-0 3' OH OH Mg2+ Incoming DNTP H. Incoming DNTP 0-P=0 Mg H. Mg CH H. Can you' rationalize or explain why dNTP (deoxyribonucleotide triphosphate) instead of DNMP (deoxyribonucleotide monophosphate) has been selected by evolution as the reactant and a DNA polymerase is also required to catalyze the reaction (to a reasonable rate of ~1000-events per second) in living systems? Hint: Ea of the reaction without catalysis is about 30 kcal/mol.

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