In mice, the autosomal locus coding for the β-globinchain of hemoglobin is 1 m.u. from the albino locus. Assume for the moment that the same is true in humans. The disease sickle-cell anemia is the result ofhomozygosity for a particular mutation in theβ-globin gene.a. A son is born to an albino man and a woman withsickle-cell anemia. What kinds of gametes will theson form, and in what proportions?b. A daughter is born to a normal man and a womanwho has both albinism and sickle-cell anemia.What kinds of gametes will the daughter form,and in what proportions?c. If the son in part (a) grows up and marries thedaughter in part (b), what is the probability that achild of theirs will be an albino with sickle-cellanemia?

11). This pedigree illustrates a family in which some members have a completely penetrant disease caused by a dominant mutation. This mutation is linked at a distance of 10 map units from a SNP marker with three different alleles (1, 2 and 3). The SNP alleles found in each family member are indicated below each pedigree symbol. It is not yet evident whether the very young individuals labeled A and B will develop the disease. a. What is the probability that individual A will develop the disease? b. What is the probability that individual B will develop the disease? 1,3 2,2 1,2 3,2 O 1,2 3,2 A B

out of 1 If one of the parents is found to have the mutation that causes DAD, it is most likely the statement) Row A. B. C D. Select one OA A OB. B OC. C OD. D i father father mother Diabetes mellitus and deafness (DAD) is a genetic disorder caused by a point mutation at position 3243 in human mitochondrial DNA (mtDNA), which consists of a circular genome. As suggested by the name, patients with DAD are subject to hearing loss at certain frequencies as well as Type 1 diabetes. mother After having a child born with DAD, a man and a woman decide to have their own DNA screened in order to determine who the mutation came from. mtDNA is coded for on the Y-chromosome mtDNA is inherited through sperm mtDNA is coded for on the X-chromosome mtDNA is inherited through ova because _ii (select the row that correctly completes the

Duchenne Muscular Dystrophy (DMD) is a disorder that primarily affects the function of skeletal muscles used for movement and cardiac muscles used for heart beating.  Dystrophin is a protein encoded by a single gene, DMD, that is expressed in skeletal and cardiac muscle.  Some forms of muscular dystrophy may be caused by different mutations in the DNA sequence of the DMD gene.  Because the DMD locus is on the X chromosome, males are affected at higher rates. Two brothers, one of whom has DMD and one of whom does not, worked with their genetic counselor (Links to an external site.) to have their DMD gene sequenced to identify genetic variation that may explain why one brother was affected and the other not. Because DMD is a very long gene, a fictionalized, simplified model of the results is presented here (Figure 1).  The actual DMD mRNA is about 16,000 base-pairs!------Consider single nucleotide polymorphism (SNP) #1 (Figure 1).  Is this mutation likely to cause Duchenne muscular…