Given a mutation in the promoter, coding region, and/or non-coding region of a gene, explain how these three scenarios create new alleles of the same gene.

Q: Describe the difference between a transcriptional fusion and a translational reporter gene fusion.…

A: Transcription fusion means cloning the promoter of interest, upstream of any transcription unit,…

Q: The wildtype sequence of a gene is the following: wt:          3' TAC AAA TCT AGC CCG 5'  and the…

A: We'll look at three distinct mutations that were discovered in a wild-type gene sequence in this…

Q: If the gene product is protein then why not to provide these protein from exogenous source to meet…

A: DNA undergoes transcription to form RNA which then undergoes translation to form DNA.

Q: Please answer  A mutation within an enhancer sequence regulating the expression of the ABC1 gene…

A: The transcription is the process by the RNA is produced from the DNA and this is the first step of…

Q: Briefly discuss why mutant allele 1 fails to produce functional protein. Note that this mutation has…

A: A gene is a DNA-based functional heredity unit that delivers instructions for the production of RNA…

Q: Give at least 3 examples each of internal and external factors that affect penetrance and…

A: Penetrance is a term used to define whether or not a genotype has a clinical expression in a person.…

Q: A principle of biology is the genetic material provides ablueprint for reproduction. Explain how…

A: The DNA (deoxyribonucleic acid) is the hereditary unit of an organism. It consists of purines and…

Q: The b1 allele encodes a transcription factor that stimulates production of anthocyanin, a purple…

A: It is given that seven tandem repeats were deleted that are located 100,000 bp upstream of the b1…

Q: Missense and nonsense mutations can occur in both the protein coding region and the regulatory DNA…

A: Is Missense and nonsense mutation occur in both protein coding region and the regulatory DNA of a…

Q: Northern blot is an analytical technique commonly performed to study gene expression in experimental…

A: A tissue is defined as a group of cells that possess a similar structure and perform a specific…

Q: Concentration (%) A researcher is studying environmental conditions that cause the expression of…

A: We analyze the correlation between pH values and active repressor concentration to identify the…

Q: How would you explain gene expression? How is it that a particular genotype is actually expressed as…

A: The central dogma is the flow of information that is carried by a gene that is expressed in the form…

Q: Suppose a researcher has three different Drosophila strains that have mutations in the bicoid gene…

A: In Drosophila the bicoid is a maternal gene. Which function is to established the anterior part like…

Q: Many genes generate different products depending on the type of cell expressing the gene. How is…

A: The process of generation of different protein products from the same pre-mRNA transcript is called…

Q: Knockout mice are mice in which a functional gene or a group of functional genes are rendered…

A: What happened when RAG1 and RAG2 genes removed to make knockout mice?

Q: Consider a single base insertion mutation between the 3rd and 4th codons in a natural gene that…

A: Amino acid  The building blocks of proteins. The protein is a polymer made up of chain of amino…

Q: 3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the…

A: The pure breeding lines of mutant and wild type organism must be crossed to determine if the…

Q: Explain how a loss-of-function allele in a gene encoding a cohesin protein could be dominant to…

A: Cornelia de Lange syndrome (CdLS) is a rare human disease caused by a dominant loss-of-function…

Q: ow will this mutation affect the process of X inactivation? A. "X inactivation will still be random…

A: E. "The normal X chromosome (no mutation in Xist) will always be inactivated" is correct option

Q: One mutation is a deletion of six nucleotides in the second exon of the gene and the other mutation…

A: Introns and exons are nucleotide sequences within a gene in mRNA. The conversion of DNA to RNA is…

Q: Why is it useful to survey expression of the entire genomeunder particular conditions?

A: Expression of the entire genome involves studying expression and the variation in expression in a…

Q: When the organization of adjacent genes with highly similar sequences is in an inverted orientation,…

A: The physical unit of heredity is known as the gene. The term "inversion" refers to a mutation that…

Q: During construction of a knockout mouse, a targeting vector is introduced into mouse embryonic…

A: Gene targeting is the technique of changing a specific sequence or gene at its location in a genome…

Q: When considering the cause of the disease in a patient who is the child of an inbred couple, it was…

A: 1. The given situation describes a child, born to an inbred couple, who is suffering from a…

Q: Describe the difference in the effects of a mutation in a gap gene versus one in a pair-rule gene.

A: The genes consist of hereditary information in the deoxyribonucleic acid (DNA) sequences and is…

Q: The HbβS(sickle-cell) allele of the human β-globingene changes the sixth amino acid in the…

A: Sickle cell anemia is a blood disorder in which an improper folding of hemoglobin occurs. In this…

Q: In humans, the average length of a gene on chromosome 7 is 69,000 base pairs, but the average mRNA…

A: DNA( deoxyribonucleic acid) is the double-stranded molecule that is the genetic material in most…

Q: Based on Figure 17-35, write a sentence stating howtranslocation can lead to cancer. Can you think…

A: Translocations were discovered cytologically for the first time in the late nineteenth and early…

Q: The number of protein-encoding genes in a prokaryotic cell equals the number of proteins that can be…

A: Genes encode proteins and dictate cellular functions. The genes expressed in a particular cell…

Q: Explain why loss-of-function hedgehog and smoothened mutations yield the same phenotype in flies,…

A: The Hedgehog signalling pathway is responsible for transferring information to embryonic cells.…

Q: explain the statement Transposons can move genes to newchromosomal locations.

A: Transposons are referred to as chromosomal segments which can undergo transposition.

Q: Briefly explain how or why making a region of DNA heterochromatic results in little or no expression…

A: DNA consists of two regions euchromatin and heterochromatin. heterochromatin are darkly stained…

Q: Fill the blank     Combinatorial strategies at the DNA level and RNA level,as well as __________…

A: gene expression is a process from which a gene on DNA is converted to RNA and from RNA to protein.

Q: Describe the two-step process that results in geneexpression.

A: A gene is the functional unit of heredity. The genes carry information responsible for the synthesis…

Q: Define the following terms:a. nonreplicative transpositionb. replicative transpositionc. composite…

A: Transposons are DNA (deoxyribonucleic acid) segments that have the internal property of movement…

Q: To cause cancer, proto-genes require blank allele(s) to be mutated and therefore are considered…

A: ANSWER;- To cause cancer, proto-genes require a single allele(s) to be mutated and therefore are…

Q: Describe how you would use replica plating of mutagenized, haploid yeast cells to identify…

A: The mutants that have a permissive temperature lower than the restrictive temperature are called…

Q: ere are e mater ganism mice th me. If a m its n

A:

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.