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Explain why a peptide (protein) ligand can’t use a receptor inside the cell while an asteroid has no problem using an intracellular receptor.
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- You can choose one or more than one option The dissociation constant (Kd) of a receptor is: BIOCHEMISTRY basic the concentration of a ligand that produces 100% occupancy of the receptor the concentration of a ligand that produces 50% of the maximal effect. the measurement of specificity between ligand and its receptor. the measurement of speed by which a ligand will dissociate from its receptor. the measurement of affinity between a ligand and its receptor and the inverse of the association constant. During an experiment with Drosophila, it was discovered that all females had red eyes. unlike males. A conclusion based on this observation would be: MOLECULAR BIOLOGY basic The gene for eye color is located on the X chromosome. The females are homozygotes The gene for eye color is dominant. The eye color results from multigenic linkage. The eye color phenotype is sex-linked A secondary lysosome: CELL BIOLOGY advanced a lysosome that provides a backup to the primary…you have been asked to develop a drug that could inhibit an enzyme linked receptor. what are the potential pharmacological targets you could design your drug to interact with. which one should you choose and whyYou are a technician in a biochemistry lab running receptor binding experiments. The target membrane-bound receptor has been partially purified from mouse, rat, and human cell lines. Using the same radioactive ligand in a saturation binding assay for each species' receptor, you generate the binding data in the table. The dependent variable, Y, is the fraction of binding sites occupied by the ligand. Ligand Y for mouse Y for rat Y for human concentration receptor receptor receptor (nM) 0.20 0.048 0.29 0.17 0.50 0.11 0.50 0.33 1.0 0.20 0.67 0.50 4.0 0.50 0.89 0.80 10 0.71 0.95 0.91 20 0.83 0.97 0.95 50 0.93 0.99 0.98 Determine the Ka for the human receptor in this binding experiment. human receptor Kd nM
- Estimate the binding affi nity of a ligand for its receptor from the followingdata:You can choose one or more than one option The dissociation constant (Kd) of a receptor is: the concentration of a ligand that produces 100% occupancy of the receptor the concentration of a ligand that produces 50% of the maximal effect. the measurement of specificity between ligand and its receptor. the measurement of speed by which a ligand will dissociate from its receptor. the measurement of affinity between a ligand and its receptor and the inverse of the association constant.Which of these amino acids would be found in the extracellular part of a receptor? Group of answer options histidine glutamine phenylalanine arginine asparagine
- Speculate on what the receptor sites for each of these molecules might be in terms of shape and polarity. Suggest an amino acid that could be part of the structure of that receptor site. What is an amino acid that would not line up with the surface properties of each of these compounds (1 for each). (Hint: you can look up the amino acids and their properties. Remember what we’ve talked about in terms of said surface properties and binding).The figure below illustrates a model of a signal transduction cascade, initiated by the bind- ing of a ligand to a membrane-bound receptor. ligand A partial model of a signal transduction pathway A inactivated molecules B -receptor protein A D activated molecule 1 Based on the figure, which of the following describes the most likely outcome of a mutation that changes the intracellular region of receptor protein A? activated molecule 2 activated molecule 3 The receptor will not activate molecule 1, but the activation of molecules 2 and 3 will continue at lower rates. Molecule 1 will not become activated, preventing the activation of molecules 2 and 3 and the subsequent cellular response. с The ligand will not be able to bind the membrane-bound receptor, preventing the signal transduction pathway from initiating. The ligand that binds to protein A will not enter the cell, preventing the cellular response from occurring.what is an evolutionarily conserved class of receptor, consisting of an integral membrane receptor protein coupled to an intracellular protein that transmits signals to the interior of the cell.
- A ligand binds two different receptors with a Kd value of 10−7 M for receptor 1 and a Kd value of 10−9 M for receptor 2. For which receptor does the ligand show the greater affinity? Calculate the fraction of receptors that have a bound ligand ([RL]/RT) in the case of receptor 1 and receptor 2 if the con- centration of free ligand is 10−8 M.The Structure of the acetylcholine receptor is shown below: A. Knowing the amino acid sequence of this protein, what tool would you use to identify the membrane-spanning region? Explain how it works.Two proteins have exactly the same amino acid sequence. Protein A is able to bind with high affinity to a cellular receptor, while Protein B cannot bind to the receptor under identical conditions. In 3-4 sentences explain, provide an explanation why two proteins with the same primary sequence could have very different abilities to bind a receptor.