you have been asked to develop a drug that could inhibit an enzyme linked receptor. what are the potential pharmacological targets you could design your drug to interact with. which one should you choose and why

What are kinases? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a Enzymes which add acetyl groups to amino acids. b Enzymes which add phosphates to amino acids. C e Enzymes which remove phosphates from amino acids. Enzymes which activate proteins in signaling cascades. Enzymes which add phosphate groups to DNA.

Amoeboid cells that migrate through our tissues, such as the class of white blood cells known as neutrophils, often do so in a directed manner, triggered, for instance, by chemical signals released by pathogens such as bacteria. Directed migration in response to a chemical stimulus is known as chemotaxis. Part of an efficient chemotactic response is the ability of cells to polarize. As is the case with our structurally-polar polymers like F-actin or microtubules, polarization here refers to an asymmetry in the cells, rather than an electrical charge. In this case, it involves one part of the cell becoming the “front” (or leading edge) and another the rear. In a well-polarized, migrating cell, it’s been observed that an active form of Rac (which, in turn, can activate ARP 2/3) is concentrated towards the front of the cell, whereas an active form of Rho (which, in turn, can activate formin, inhibit cofilin/ADP, and activate myosin II) is found toward the rear of the cell. Based on your…

compare the structures of the peptide neurotransmitters Met-enkephalin and Leu-enkephalin

I don't understand, can I get help? I have attached a picture of everything that will be needed to be annotated. Numerous signaling molecules work together in order for glucagon to induce the regulated release of glucose into the bloodstream. Construct an annotated list of each of these signaling molecules (as learned in the lecture video). For your annotated list, please use the format below. You will need to use this format for each molecule in the pathway that we learned.  Name of Molecule:Type of Molecule:Is activated (or inhibited) by:Activates (or inhibits):

For each of the following examples, indicate whether the drug is acting on physical process, chemical process or enzymatic system (your answer should be only; Physical, Chemical or Enzymatic).   A. A drug is used as an antidote in lead poisoning and acts by binding to lead particles in body (chelation therapy). B. A drug acts to reduce flatulence and acts by reducing the surface tension of intestinal gas bubbles in the GI tract (e.g. Simethicone). C. A drug competes with alpha-glucosidase in intestine to reduce glucose conversion from disaccharides (e.g. Acarbose).

Mutant tyrosine kinase signaling proteins are implicated in many types of human cancer. Hundreds of millions of dollars are required for the basic research and development of a new drug. Tyrosine kinase inhibitor drugs have been approved for cancer treatments by the U.S. Food and Drug Administration. What do you think would be some of the difficulties of finding these drugs given that similar kinases are active in normal cells? Do you think new medications of this type should be developed through government-sponsored research? Why or why not? If not, what alternatives do you propose?

What are the potential interactions between a specific medication used to treat a cardiovascular condition and a newly discovered compound derived from a rare plant species, and how might these interactions impact the pharmacokinetics and therapeutic efficacy of the medication?

A patient is receiving morphine sulfate intravenously via a patient controlled analgesia (PCA) pump. The concentration of the solution is 11 mg/mL and is being infused continuously around the clock at a rate of 0.1 mL/hr. The patient may also access a 2-mg bolus dose every hour for breakthrough pain if needed and they are currently using an average of 5 additional bolus doses per day. The patient is to be converted to fentanyl using the table below. But before using the table we must determine their morphine usage, so what is this patient's total daily dosage of IV morphine? TABLE 10.3 FENTANYL TRANSDERMAL DOSAGE CONVERSION GUIDELINES", b Current Analgesic Oral morphine IM/IV morphine Oral oxycodone Oral codeine Oral hydromorphone IV hydromorphone IM meperidine Oral methadone 60-134 10-22 30-67 150-447 8-17 1.5-3.4 75-165 20-44 Recommended fentanyl transdermal system dose Fentanyl transdermal system 25 mcg/h Daily Dosage (mg/day) 135-224 23-37 67.5-112 17.1-28 3.5-5.6 166-278 45-74…

What are conformational changes and why are they important ? Then describe two examples of conformational changes and their impacts during cellular signaling.