describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY. Choose from the 4 following effects: Initiation of DNA synthesis okazaki fragment synthesis Leading strand elongation lagging-strand completion --> Explain why these mutant strains are most likely temperature-sensitive mutants

describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY. Choose from the 4 following effects: Initiation of DNA synthesis okazaki fragment synthesis Leading strand elongation lagging-strand completion --> Explain why these mutant strains are most likely temperature-sensitive mutants

Name: , describe the normal role of the component, and choose from the selec
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Description: , describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY.Choose from the 4 following effects:Initiation of DNA synthesis okazaki fragment synthesisLeading strand elong

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 9QP: Define and compare the following types of nucleotide substitutions. Which is likely to cause the...

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, describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY. Choose from the 4 following effects: Initiation of DNA synthesis okazaki fragment synthesis Leading strand elongation lagging-strand completion --> Extracts from a strain of bacteria lacking the 5’ to 3’ exonuclease activity of DNA polymerase
, describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY. Choose from the 4 following effects: Initiation of DNA synthesis okazaki fragment synthesis Leading strand elongation lagging-strand completion -->Extracts from a strain of bacteria lacking primase activity
Extreme UV exposure leads to the SOS response in bacteria. By what mechanism does the SOS response function? Answer choices induction of photolyase and the addition of white light to remove the thymine dimer destruction of lexA, which leads to expression of an alternate, error-prone DNA polymerase homologous recombination repair non-homologous end joining exinuclease removal of a segment of DNA including a thymine dimer, followed by the replacement of DNA using the complementary strand of DNA
Give 1 example of diseases arising from each of the following mutations and explain each. Point mutation Frameshift mutation Calculate for the DNA concentration. The absorbance at 260 nm is 0.7 at 1:30 dilution; the absorbance at 320 nm is 0.1. Is the DNA isolated of good quality? The absorbance at 260 nm is 0.7; the absorbance at 280 nm is 0.1; the absorbance at 320 is 0.01. If you do an absorbance reading after plasmid purification and get an A260/A280 of less than 1.8, how could you further purify the sample to get rid of the protein contamination? Is it always necessary to have completely pure DNA? What are some cases where it would or would not be?
Induced mutation are characterized by: Select the correct response: Exposure to free radicals that has been deposited in the aqueous phase and diffuses towards the cell that is followed by the inhibition of its replication or transcription, or may cause deletion. Physical and chemical agents that results in the transition, transversion, and framshift mutations of bases and other structural units that affects the overall function of a nucleic acid. Physical and chemical agents that results in the alteration of the electoronic characteristics of the bases and other structural units that affects the overall function of a nucleic acid. Point mutations that results in the transition, transversion, and framshift mutations of bases and other structural units that affects the overall function of a nucleic acid. Physical and chemical agents that results in the alteration base pairing where tautomers are formed affects the overall function of a nucleic acid.
A certain section of the coding (sense) strand of some DNA looks like this: 5'- ATGGGCCACTCATCTTAG-3' It's known that a very small gene is contained in this section. Classify each of the possible mutations of this DNA shown in the table below. I Don't Know mutant DNA 5'- ATG GGCCACAGTTCTTAG-3' 5'- ATG GG CTCATCTTAG - 3' 5'- ATG GGCCACGCATCTTAG-3' Submit type of mutation (check all that apply) ооооо O point O silent O noisy ооооо insertion deletion insertion O deletion Opoint Osilent noisy insertion O deletion ооооо Opoint silent O noisy X S Ⓒ2023 McGraw Hill LLC. All Rights Reserved. Terms of Use | Privacy Center Accessibility
Faulty DNA repair; ii) Gain-of-function; and iii) Trinucleotide repeats provide genetics disorders Give examples of mutations with each disorder.
a. As a result of the structure of DNA and RNA, replication, transcription and translation are possible. What can nucleic acids do, as a result of their structure, that enables these processes to occur? The figure below shows a simplified schematic representation of a segment of DNA. The DNA is labelled with the numbers 1 – 14 for easy reference. -35 sequence Pribnow box 5' UTR 3' UTR DNA TTGACA TATAAT -35 -10 Gene a Gene B Gene y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 UTR = untranslated region b. At which position on the DNA (number 1 - 14) will transcription be initiated? c. At which position on the DNA (number 1 - 14) will the first signal for translation be found? d. Between which two regions on the DNA will the polyadenylation signal be found? Use the numbers to indicate the region. e. Between which two regions on the DNA will the first Shine-Dalgarno / Ribosome Binding Sequence be found? Use the numbers to indicate the region.
a. Propose three different mutations to prevent initiation, elongation, and termination of bacterial DNA replication, respectively. Explain how/why each mutation would prevent its respective step. (Hint: mutations can be in genes that encode proteins or regulatory DNA sequences) b. In the early 1900s, Avery, MacLeod, and McCarty performed an experiment in bacterial cells to determine whether DNA, RNA, or protein functions as the 'transforming molecule' (i.e. the genetic material). In your own words, how did their experiment (depicted in the figure below) help to answer that question?
Explain why base excision repair, nucleotide excision repair, and mismatch repair—which all require nucleases to excise damaged DNA—require DNA ligase.
Exposure to various chemicals can cause DNA mutations. Classify the examples as representative of transition, transversion, or nsertion/deletion mutations. Transition replacement of T:A: with C:G treatment with nitrogen mustard causes this type of mutation oxidative deamination via nitrous acid causes this type of mutation treatment with 5-bromouracil causes the replacement of A:T with G:C Transversion replacement of G:C with T:A Answer Bank Insertion/Deletion the removal of one or more base pairs treatment with proflavin causes this type of mutation
Isein) are shówn in the following document: Codon Number Base Sequence of Normal DNA Transcribed Strand ТАС ТСС СТС AAT СТ AAT TTG Base Sequence of Abnormal DNA Transcribed strand ТАС ТСС СТС AAT CTT ATT TTG 7. Compare the 2 DNA sequences and explain the absence of functional casein in abnormal females.