Question one parts A though Hd. You have a plan to make the cellular signaling peptide RGD (Arg-Gly-Asp). If you are beginning fromthe Arginine (Arg) amino acid, which amino acid(s) will require NH2 protection to optimize thea. Look at the non-natural amino acid below and note that the pka's of particular groups are provided.synthesis?Determine the Isoelectric point of this amino acid (pl). Please answer as a letter choice only (i.e., "E"not "E)"A) All 3 amino acids will need NH2 protectionB) Gly and Asp will need NH2 protectionC) Arg and Gly will need NH2 protectionpka = 4.20 HOноКа 2.00HO,D) Only ArgNH,pКа 9.50E. Which of the following amino acids will not produce a purple color (indicative of 2 ninhydrinmolecules binding) when reacted with ninhydrin?A) pl = 6.20B) pl = 3.10A) phenylalanineC) pl = 5.23D) pl = 5.75B) valineC) prolineb. Which drawing best indicates the form of the amino acid at a pH of 8.4?D) histidineF. If you had a mixture of leucine, arginine, and glutamic acid in a pH of 6 and applied a drop onto paperconnected to an electrophoresis apparatus. Which of these would move toward the cathode (-).pka -2.00HO.pka = 4.20HOA) LeucineNH,pka -9.50B) ArginineC) Glutamic AcidA.В.D) None of themно,OHHO.G. True/False - Dicyclohexylcarbodiimide is a typical reagent in peptide synthesis for protectingNH,NH,carboxylic acid groups.C.D.H. True/False t-butoxycarbonyl dicarbonate (Boc20) adds a t-butoxy carbonyl group to the amineно.NH,NH3portion of the amino acid creating an amide (carbamate) and protects the amine portion from sidereactions.c. Which of the following dipeptides is leucinylserine?A.B.OHH,N.OHH,N.OHноD.C.OHHN.OHHN.онно

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a. Look at the non-natural amino acid below and note that the pka's of particular groups are provided. Determine the Isoelectric point of this amino acid (p). Please answer as a letter choice only (i.e, "E" not "E)" pka - 4.20 HO. pKa = 2.00 HO. NH, pka - 9.50 A) pl = 6.20 C) pl = 5.23 B) pl = 3.10 D) pl = 5.75 b. Which drawing best indicates the form of the amino acid at a pH of 8.4? pka4.20 pka2.00 NH, pka950 HO. NH, NH, c. Which of the following dipeptides is leucinyiserine? HN. но D. OH он OH HO

a. Look at the non-natural amino acid below and note that the pka's of particular groups are provided. Determine the Isoelectric point of this amino acid (p). Please answer as a letter choice only (i.e, "E" not "E)" pka - 4.20 HO. pKa = 2.00 HO. NH, pka - 9.50 A) pl = 6.20 C) pl = 5.23 B) pl = 3.10 D) pl = 5.75 b. Which drawing best indicates the form of the amino acid at a pH of 8.4? pka4.20 pka2.00 NH, pka950 HO. NH, NH, c. Which of the following dipeptides is leucinyiserine? HN. но D. OH он OH HO

Organic And Biological Chemistry

7th Edition

ISBN:9781305081079

Author:STOKER, H. Stephen (howard Stephen)

Publisher:STOKER, H. Stephen (howard Stephen)

Chapter9: Proteins

Section: Chapter Questions

Problem 9.58EP

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