Chemistry Given TETRAPEPTIDE: Prolinyl-Argininyl-Cysteinyl-Tryptophan Predict the direction of the peptide in electrophoresis at pH 7 and pH11.5. (Use table on the upper right for the estimated pK values of some functional groups).

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chemistry

Given TETRAPEPTIDE: Prolinyl-Argininyl-Cysteinyl-Tryptophan

Predict the direction of the peptide in electrophoresis at pH 7 and pH11.5. (Use table on the upper right for the estimated pK values of some functional groups).  

iven the tetrapeptide:
O=
HN
H
NH₂
C
NH
CH₂
CH₂
CH₂
0=
H
O
CH₂
SH
•N
H
U O
NH
6
Dissociating Groups in Proteins pk Range
a-carboxyl group
a-amino group
Non a-COOH of Asp or Glu
Soft
Sulhydryl of Cysteine
Hydroxyl of Tyrosine
Imidazole of His
&-Amino of Lysine
Guanidine of Arginine
2.0
10
4.0
8.5
10.0
6.5
10.4
12.0
Transcribed Image Text:iven the tetrapeptide: O= HN H NH₂ C NH CH₂ CH₂ CH₂ 0= H O CH₂ SH •N H U O NH 6 Dissociating Groups in Proteins pk Range a-carboxyl group a-amino group Non a-COOH of Asp or Glu Soft Sulhydryl of Cysteine Hydroxyl of Tyrosine Imidazole of His &-Amino of Lysine Guanidine of Arginine 2.0 10 4.0 8.5 10.0 6.5 10.4 12.0
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