5. A histidine residue (His146) in Hb subunit has a side chain pKa of 6.2 in the lung. Due to a conformational shift of Hb in the muscle, an amino acid moves into the close proximity of this histidine, shifting this His146 pka to 7.7: • a) what is the net charge of this His146 in the lung at pH 7.6 (show all the calculations)? • b) what is the net charge of this His146 in the muscle at pH 7.2 (show all the calculations)? • c) what is the likely identity of the residue that causes the pKa shift for His146 residue? Explain why such residue causes the shift in the histidine pka.

5. A histidine residue (His146) in Hb subunit has a side chain pKa of 6.2 in the lung. Due to a conformational shift of Hb in the muscle, an amino acid moves into the close proximity of this histidine, shifting this His146 pka to 7.7: • a) what is the net charge of this His146 in the lung at pH 7.6 (show all the calculations)? • b) what is the net charge of this His146 in the muscle at pH 7.2 (show all the calculations)? • c) what is the likely identity of the residue that causes the pKa shift for His146 residue? Explain why such residue causes the shift in the histidine pka.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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