Answered: A pharmaceutical mixture consisting of…

Introduction to Chemical Engineering Thermodynamics

8th Edition

ISBN:9781259696527

Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart

Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart

Chapter1: Introduction

Section: Chapter Questions

Problem 1.1P

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Question

A pharmaceutical mixture consisting of 52 mass % A and the balance B. The particles are spherical. The particle density of A is 400 and that of B is 700 kg/m³. The cumulative undersize mass distributions of the two components are shown below. If samples of 1 g (corresponding to a single dose) are withdrawn from the mixture, determine the following:

size (µm)

450 500 600 700 850 1000 1200 1400 1700 2100

N3_A (cumulative A undersized by mass)

0, 0.015, 0.038, 0.078, 0.171, 0.6, 0.886, 0.948, 0.975, 1

N3_B (cumulative B undersized by mass)

0, 0, 0.045, 0.13, 0.34, 0.76, 0.91, 0.97, 1, 1

total number of particles of component A in a 1 g of pure A
total number of particles of component B in a 1 g of pure B
expected standard deviation between the samples for a random mix of the composition in % based on number using the equation of Lacy
expected standard deviation between the samples for a mixture in an unmixed state of the composition in % based on number using the e

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