Need help with this question please, thank you. 1.) The protein SIRT6 has been shown to be important in energy metabolism and inflammatoryresponses. The authors of a recent paper indicate that increasing expression and activity ofSIRT6 may be beneficial in neurodegenerative diseases, diabetes and arthritis. The protein hasdeacetylase activity. The authors watched the disappearance of a nitro-fatty acid as a functionof time in a reaction catalyzed by human Sirt6 as below.J. Biol. Chem. jbc.RA120.014883. doi:10.1074/jbc.RA120.014883Absorbance 330 nm0.080.060.040.020.00■0 246■8t (min)10 12 14 16a) How is the absorbance related to the fraction (0) of the reactant remaining?b) Is there evidence that the reaction is first order in this reactant concentration?

Enzyme are proteins that catalyse biochemical reactions. An enzyme's activity refers to the rate at…

Answered: 1.) The protein SIRT6 has been shown to…

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter4: Cells

Section: Chapter Questions

Problem 1ITD

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Similar questions

During fatty acid biosynthesis, is it correct that the product detaches from fatty acid synthase complex when the chain length is 16 carbons?
Define beta-oxidation of fatty acids? Describe in detail three different steps of beta-oxidation of FAs.
Insulin resistance, as occurs in type 2 diabetes, may lead to increased ketone production and release into blood. Describe the biochemistry that links insulin resistance and ketone production. Compare the cellular energy (e.g. ATP) required and produced when glycogen is synthesize and hydrolyzed, respectively. Compare and contrast the mechanism of fatty acid synthase with translation. When young rats are placed on a totally fat acid free diet, they grow poorly, develop a scaly dermatitis, lose hair, and soon die these symptoms that can be prevented if plant material is included in the diet. Why?
n a particular enzyme, an alanine residue is located in a cleft where the substrate binds. A mutation that changes this residue to glycine has little effect on activity; however, another mutation, which changes the alanine to a glutamate residue, leads to a complete loss of activity. Provide a brief explanation for these observation
Is the statement during fatty acid biosynthesis, the product detaches from fatty acid synthase complex when the chain length is 16 carbons, wrong or right?
If a slight deficiency in the Vitamin B1 derivative Thiamine Pyrophosphate (TPP) leads to an accumulation of substrates for reactions utilizing this cofactor, A) what substrates would ‘accumulate’ in a human after eating a an enormous amount of sugar-laden Halloween candy, AND what would be the regulatory consequences on carbohydrate metabolism? B) what substrates would accumulate in yeast cells cultured under anaerobic (no oxygen) conditions AND what would be the regulatory consequences on carbohydrate metabolism? C) and lastly, what substrates would accumulate in plant cells incorporating carbon and generating energy solely using photosynthesis?
If a slight deficiency in the Vitamin B1 derivative Thiamine Pyrophosphate (TPP) leads to an accumulation of substrates for reactions utilizing this cofactor, A) what substrates would ‘accumulate’ in a human after eating a an enormous amount of sugar-laden Halloween candy, AND what would be the regulatory consequences on carbohydrate metabolism? B) What substrates would accumulate in yeast cells cultured under anaerobic (no oxygen) conditions AND what would be the regulatory consequences on carbohydrate metabolism? C) What substrates would accumulate in plant cells incorporating carbon and generating energy solely using photosynthesis?
A3 Glucosylacetamide has a structure similar to the transition state during catalysis by the enzyme hexokinase and therefore would likely be A. covalently attached to hexokinase at a regulatory site distinct from the active site. B. covalently bound to an active site amino acid of hexokinase. C. a high-affinity hexokinase inhibitor. D. more rapidly hydrolyzed than ATP during catalysis.
The clinical symptoms of two forms of galactosemia—deficiency of galactokinase or of UDPglucose: galactose 1-phosphate uridylyltransferase—show radically different severity. Although both types produce gastric discomfort after milk ingestion, deficiency of the transferase also leads to liver, kidney, spleen, and brain dysfunction and eventual death. What products accumulate in the blood and tissues with each type of enzyme deficiency? Estimate the relative toxicities of these products from the above information.
Describe two types of regulation of the enzyme glutamine synthetase and explain why the regulation of this enzyme is soooo complex.
PLP is a cofactor for a number of enzymes involved in amino acid metabolism. Give an example of reaction in which PLP participates in cleavage of the a, b, and c bonds of an amino acid, as diagrammed in shown Fig.
The M and H subunits of lactate dehydrogenase have very similar sizes and shapes but differ in amino acidcomposition. If the only difference between the two were that theH subunit had a glutamic acid in a position where the M subunithad a serine, how would the five isozymes of LDH separate on electrophoresis using a gel at pH 8.6?

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