Please, please I do not understand this question for Biochemistry. Can you help me? Steps leading to the correct answer would be helpful! Chymotrypsin is a digestive enzyme with a catalytic optimum between pH 7.8 and 8.0. However, due to the presence of gastric juice, chymotrypsin often functions in an environment of pH 5.5–7.0.The imidazole group of free histidine has a pKₐ of 6.0. Use the Henderson–Hasselbalch equation to determine the ratio of deprotonated to protonated His 57 imidazole moieties at pH 5.9.\[ \text{pH} = \text{p}K_a + \log \left(\frac{[\text{A}^-]}{[\text{HA}]}\right) \]\[\left[\frac{\text{His}}{\text{His}^+}\right] = \text{(input box)}\]Aside from positioning, what do you think is the role of the Asp 102 residue?- ○ It allows nucleophilic attack by His 57.- ○ It protonates His 57 prior to substrate binding.- ○ It decreases the \(\left[\frac{\text{His}}{\text{His}^+}\right)\) ratio.- ● It raises the pKₐ of His 57.There's a diagrammatic representation involving a fraction indicating the ratio of \([\text{His}]/[\text{His}^+]\), with a tools button option labeled \(x10\).

Proteases are enzymes that cleave peptide bonds that link two amino acid residues together.…

Chymotrypsin is a digestive enzyme with a catalytic optimum between pH 7.8 and 8.0. However, due to the presence of gastri juice, chymotrypsin often functions in an environment of pH 5.5-7.0. The imidazole group of free histidine has a pK₂ of 6.0. Use the Henderson-Hasselbalch equation to determine the ratio of deprotonated to protonated His 57 imidazole moieties at pH 5.9. pH = pK₁ + log ( [AA]) [His] [His+] x10 TOOLS Aside from positioning, what do you think is the role of the Asp 102 residue? It allows nucleophilic attack by His 57. It protonates His 57 prior to substrate binding. [His] It decreases the ratio. [His+] ● It raises the pka of His 57.

Chymotrypsin is a digestive enzyme with a catalytic optimum between pH 7.8 and 8.0. However, due to the presence of gastri juice, chymotrypsin often functions in an environment of pH 5.5-7.0. The imidazole group of free histidine has a pK₂ of 6.0. Use the Henderson-Hasselbalch equation to determine the ratio of deprotonated to protonated His 57 imidazole moieties at pH 5.9. pH = pK₁ + log ( [AA]) [His] [His+] x10 TOOLS Aside from positioning, what do you think is the role of the Asp 102 residue? It allows nucleophilic attack by His 57. It protonates His 57 prior to substrate binding. [His] It decreases the ratio. [His+] ● It raises the pka of His 57.

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

QUESTION 10 Select all of the true statements regarding the molecule below: NH, -P-O NH G OH NH, О-Р-О- H,N N- A ОН -P-O `NH U ОН 0-P-O- N' ОН ОН This is RNA This is DNA This chain is a polymer. The backbone of these nucleotides is a ribose sugar This nucleic acid is the hereditary material for humans. This nucleic acid is the hereditary material for coronaviruses. This type of nucleic acid is never found in healthy human cells. This nucleic acid contains the nucleobase thymine.
Question #3: CRISPR has been used to cure an individual from sickle cell. Below is a Sanger electropherogram of a sequence from a patient without sickle cell and one with sickle cell. Sequence from a normal individual mmmm Sequence from the diseased individual G T GIIC A GC A Se SCIENCEphe A G A SCIENCE SCIENCEphoto G a) Where is the change in the sequence and what is the consequence to the protein sequence of this mutation? b) Below is an image of the normal and diseased quaternary hemoglobin protein. What is different about the protein shape and why does that structure have a huge impact on its function (please name the function!)? Adult haemogBRAR G G G G A G Sickle Cell haemoglobin S Structure a s RARY COLIBRARY c) If you were to use CRISPR to modify the genome of a diseased individual, to which nucleotides might you design your guide RNA? Why? d) RNA Seq is used to determine off-target effects of Cas9 cleavage. Why is this an appropriate tool to determine these effects? e) Data on…
Please select the correct answer.
Question:- 1. Describe an assay that could measure the activity of adenylyl cyclase (AC).
Please try instead of just declining the question. I don't understand it
Please answer
Please send me the question in 20 minutes it's very urgent plz find
Question 1: A. In Northern blotting, electrophoresis is used to resolve which biological molecules? What type of probe is used to identify the target molecule(s)? B. In Southern blotting, electrophoresis is used to resolve which biological molecules? What type of probe is used to identify the target molecule(s)? C. In Western blotting, electrophoresis is used to resolve which biological molecules? What type of probe is used to identify the target molecule(s)? D. Which of these techniques gives information about the expression levels of genes?
I need the answer quickly
Rare gain-of-function mutations cause increased _______________production, synthesis of an altered protein, or productionof the normal protein in the wrong context.?
I need the answer as soon as possible
Question 11 (1 point) Endoplasmic Reticulum 1) Carbohydrates 2) Proteins 3) Nucleic Acids 4) Lipids