Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter A, Problem 5P
A woman, S.R., had a maternal grandfather with hemophilia A (OMIM
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A mother is heterozygous for the X-linked gene for colorblindness and also heterozygous for the autosomal inherited sickle cell anemia. She is married to a man who can see color normally and who is heterozygous for sickle cell trait. Using b (colorblind), B (normal color), S (normal hemoglobin), s (sickle cell), answer the following: a. What are the genotypes of the parents? b: What is the probability of having a child who is both color blind and has sickle cell anemia?
A form of hemophilia is caused by a sex-linked (X-linked) recessive gene. A phenotypically normal woman whose father had hemophilia marries a man who suffers with hemophilia. What is the probability that their first daughter will have hemophilia?
For the Y-linked gene, use T for hypertrichosis. For X-linked genes, use the letters H for blood trait and E for eye trait.
Krisha, a carrier of the genes for hemophilia and colorblindness, is married to Kyle who is color blind, having normal red blood cells.
Veronica (Krisha & Kyle's daughter), turned out to be a carrier for both genes.
Julian has hypertrichosis and is married to Josie. Both do not exhibit any allele for color blindness and never had any history for hemophilia.
Bernard (Julian & Josie's son) will be married to Veronica.
What are the complete genotypes of the following persons:
a. Krisha
b. Kyle
c. Veronica
d. Julian
e. Josie
f. Bernard
g. Josie & Bernard's baby
Chapter A Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. A - Match each statement (a-e) with the best answer...Ch. A - Go online to the Mendelian Index of Man (OMIM)...Ch. A - A.3 A couple comes into your genetic counseling...Ch. A - A man, J.B., has a sister with autosomal recessive...Ch. A - A.5 A woman, S.R., had a maternal grandfather with...Ch. A - A.6 A -year-old woman whose father had Huntington...
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- Hemophilia A is caused by a recessive X-linked allele that encodes a defective form of a clotting protein. If a affected father and a mother who is known to not be a carrier have children, what percentage of female offspring will have hemophilia?arrow_forwardCan a son be a carrier for an X-linked trait? Explain.arrow_forwardA man who has color blindness and type O blood has children with a woman who has normal color vision and type AB blood. The woman’s father had color blindness. Color blindness is determined by an X-linked gene, and blood type is determined by an autosomal gene. a. What are the genotypes of the man and the woman? b. What proportion of their children will have color blindness and type B blood? c. What proportion of their children will have color blindness and type A blood? d. What proportion of their children will be color blind and have type AB blood?arrow_forward
- Duchenne Muscular Dystrophy (DMD) is an X-linked recessive trait. Fill in a Punnett square for a man with DMD and a woman who carries DMD. Then use your Punnett square to answer the following questions: A) What is the probability that one of their daughters will have DMD? ___% B) What is the probability that one of their daughters is a carrier of DMD? ______ % C) What is the probability that one of their sons will have DMD? ______ % D) What is the probability that one of their sons is a carrier of DMD? ______ % E) On which chromosome is the gene for DMD located? _____arrow_forwardThe gene for polydactyly (P) is autosomal and dominant to normal fingers (p). Hemophilia is sex-linked and recessive (X h ). A man and his wife both of whom are polydactylous and have normal red blood cells have a child who is non-polydactylous and with hemophilia. What are their genotypes?arrow_forwardAn individual with 46, XX genotype is diagnosed with Duchenne-type Muscular Dystrophy, a recessive X-linked disorder. Genetic tests confirm that this individual is a heterozygote for this disorder. Briefly, but specifically, explain how it’s possible that they are showing symptoms of this disorder.arrow_forward
- A man with X-linked color blindness marries a woman with no history of color blindness in her family. The daughter of this couple marries a normal man, and their daughter also marries a normal man. What is the chance that this last couple will have a child with color blindness? If this couple has already had a child with color blindness, what is the chance that their next child will be color blind?arrow_forwardIn humans, the genes for red-green color blindness (R = normal, r = color blind) and hemophilia A (H = normal, h = hemophilia) are both X-linked and only 3 map units apart. Suppose a woman has four sons, and two are color blind but have normal blood clotting and two have hemophilia but normal color vision. What is the probable genotype of the woman? HR/hr Hr/hr hr/hR Hr/hR HR/Hrarrow_forwardA woman who is a carrier for X-linked hemophilia (she does not have the disease) marries a man who does not have hemophilia. They have a daughter, named Angela, who does not have the disease. Angela marries George, who also does not have hemophilia. Angela and George have a son named Robbie. What is the chance that Robbie will have hemophilia? O 1/4 O 1/3 O 1/2 0 1/8arrow_forward
- Hemophilia is a sex-linked recessive trait. A male hemophiliac and phenotypically normal female have a son with hemophilia. They would like to have one more child. What is the probability of having a child without hemophilia? Explain using a Punnett square. Is it possible for a girl to be born with hemophilia? Explain.arrow_forward3) Queen Victoria of England, who ruled from 1837-1901, is believed to have been the carrier of hemophilia. Hemophilia is an X-linked disease in which the blood is unable to form clots. Please make a Punnet Square using the scenario below and answer the following questions. Queen Victoria married a man who did not have the hemophilia trait or disease. What is the likelihood that they would have a child with hemophilia? What is the likelihood that they would have a son with hemophilia? What is the likelihood that they would have a daughter with hemophilia?arrow_forwardHemophilia is due to a sex-linked gene. It is recessive and found on the X chromosome. A woman who is a carrier for hemophilia marries a normal man. What will be the possible phenotypes of their children? (use the letter “H”)arrow_forward
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