Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter A, Problem 4P
A man, J.B., has a sister with autosomal recessive galactosemia (OMIM
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Chapter A Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. A - Match each statement (a-e) with the best answer...Ch. A - Go online to the Mendelian Index of Man (OMIM)...Ch. A - A.3 A couple comes into your genetic counseling...Ch. A - A man, J.B., has a sister with autosomal recessive...Ch. A - A.5 A woman, S.R., had a maternal grandfather with...Ch. A - A.6 A -year-old woman whose father had Huntington...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s great-grandmother also had galactosemia. Sara has a sister who has three children, none of whom is affected. What is the probability that Salim and Sara’s first child will have galactosemia? Explain your calculations.arrow_forwardSalim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara has a sister who has three children, none of whom is affected. Sara dad has no history in his family of any sign of the diease and it is assumed to be homozygous normal. What is the probability that salim and saras first child will have galactosemia?arrow_forwardparents, but her brother Alonzo has Galactosemia. Brice has a similar family history. He and his parents are healthy, but his sister Brianna has galactose, a component of the lactose found in mammalian milk. Galactosemia can be galactosemia. Amanda and Brice are planning on marrying and starting a family and partially managed by eliminating dietary intake of lactose and galactose. Amanda is Galactosemia is an autosomal recessive disorder caused by the inability to metabolize seek genetic counseling. Based on the information provided, complete the following: healthy, as are her A piaw a pedigree that includes Amanda, Brice, their siblings, and parents. Identily the genotypes of each person using G and a to represent the dominant and recessive alleles. B What is the probability that Amanda is a carrier of the allele for galactosemia? Same question for Brice? Explain. non bard bito te over ovodaarrow_forward
- 152 Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. If they have a normal child, what is the probability that he or she will be heterozygous? If they have three children, what is the probability of having 2 affected children and one normal child?arrow_forwardYour brother has an autosomal recessive disorder, while you are unaffected. Neither one of your parents is affected. Explain how this is possible.arrow_forwardMr. and Mrs. Jones have six children. Three of them have attached earlobes (recessive) like their father, and the other three have free earlobes like their mother. What are the genotypes of Mr. and Mrs. Jones and of their numerous offspring?arrow_forward
- Alberta is phenotypically normal, but her brother (Rodrigo) has albinism, which is caused by an autosomal recessive mutation. The probability that Alberta is a carrier (i.e., heterozygous for albinism) is [express your answer as a fraction]arrow_forwardPompe disease is a glycogen storage disorder caused by a lack of a-glucosidase, the enzyme that converts glycogen to glucose in the muscles. Babies born with this disorder die by the age of two. Pompe disease is a genetic disorder caused by the presence of two recessive autosomal alleles. A man and a woman heterozygous for the condition have two female unaffected children. Determine the probability, expressed as a whole number percentage, of a third baby being born a male with Pompe disease. Your answer must include the use of a Punnett square as well as a legend indicating the allele symbols used.arrow_forwardPompe disease is a glycogen storage disorder caused by a lack of ⍺-glucosidase, the enzyme that converts glycogen to glucose in the muscles. Babies born with this disorder die by the age of two. pope disease is a genetic disorder caused by the presence of two recessive autosomal alleles. A. A man and a woman heterozygous for the condition have two female unaffected children. Determine, using a Punnett square, the probability, expressed as a whole number percentage, of a fourth baby being born a male with Pompe disease. B. Iftheman,fromthepreviousquestion,hadtypeAbloodandthewomanhadtypeO blood, what would be probability of them having a daughter with type O blood and affected with Pompe disease? (Show clearly your calculations and express your answer as a frequency between 0 - 1 and rounded to 2 decimal places)arrow_forward
- Muffy, a color blind female with blood type A (heterozygous to type O) is married to Biff, who is also color blind and is homozygous for type B blood. Muffy has been having an affair with their gardener, Raoul, who is heterozygous for type B blood and has normal vision. Recall that color blindness is a sex linked recessive condition. Please help Biff's attorney determine the father of each of the children for the divorce proceedings. Show ALL work using punnett squares. a) female, type A blood, normal vision b) male, type O blood, color blind c) female, type AB blood, color blindarrow_forwardSickle cell anemia is a human genetic disorder caused by an autosomal recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?arrow_forwardPhenylketonuria (PKU) is an autosomal recessive disease that results from a defect in an enzyme that normally metabolizes the amino acid phenylalanine; when this enzyme is defective, high levels of phenylalanine cause brain damage, in the past, most children with PKU became intellectually disabled. Fortunately, intellectual disability can be prevented in these children by carefully controlling the amount of phenylalanine in the diet. The diet is usually applied during childhood when the brain development is taking place. As a result of this treatment, many people with PKU now reach reproductive age. Children born to women with PKU (who are no longer on a phenylalanine-restricted diet) frequently have low birth weight, developmental abnormalities, and intellectual disabilities. However, children of men with PKU do not have these problems. QUESTION: Describe the results depicted in Fig. 1 Use the first question to provide an explanation for these observations. What type of genetic…arrow_forward
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