Campbell Essential Biology with Physiology (6th Edition)
Campbell Essential Biology with Physiology (6th Edition)
6th Edition
ISBN: 9780134711751
Author: Eric J. Simon, Jean L. Dickey, Jane B. Reece
Publisher: PEARSON
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Chapter 9, Problem 8SQ
Summary Introduction

To explain: The chances of the occurrence of the Duchenne muscular dystrophy, which is a sex-linked recessive disorder in the second progeny of a couple named Carla and Rudy, if their first son has this disease

Introduction: The disease Duchenne muscular dystrophy is a sex-linked recessive disease, which is caused due to a cross between a male and a female named Carla and Rudy, which are carriers for the disease. It causes the weakness of the muscles of the human body. The first son of the couple is affected and the chance of the occurrence of the disease is 25% (percentage) in the second child as both the parents are carriers of the disease. The effect is only on one of the chromosome in both the parents, where mutation takes place in a single allele of a gene.

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Duchenne muscular dystrophy is a sex-linked recessive disorder characterized by a progressive loss of muscle tissue. Neither Carla nor Rudy has Duchenne muscular dystrophy, but their first son does have it. What can you say about Rudy's or Carla's genotype in relation with the disorder? If the couple has a second child, what is the probability that he or she will also have the disease? Show your answers with a Punnet square.
Jan and Michael are both carriers for the cystic fibrosis allele. If Jan and Michael have five children, what the probability that three or more of the children will have the disease?
Bob and Joan know from a blood test that they are each heterozygous (carriers) for the autosomal recessive gene that causes sickle cell disease. If their first three children are healthy, what is the probability that their fourth child will have the disease?
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