Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 8.4, Problem 2GR
Summary Introduction
To determine: The pros and cons of the outcome if genetic tests become lower in prices than existing genetic tests.
Introduction: Genetic tests are used to identify the change at chromosome, protein or gene level. The suspected genetic condition in an individual can be ruled out by the results of genetic tests. The chances of developing a genetic disorder can also be interpreted by the results of genetic tests. Newborn screening, carrier testing, prenatal testing, and pre implantation testing are the examples of available genetic tests.
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A graduate student who has not taken BIOL 519 thinks they have discovered a new oncogene that could cause breast cancer. The student transfects cells with this oncogene and finds that the cells proliferate uncontrollably. The student next designs a PCR assay that will detect the presence of the oncogene in cancerous breast tissue. The student sets up the assay and analyzes the presence of the oncogene in normal and tumor issue samples (See data below). The student is disappointed to see that the potential oncogene is present at similar levels in both the normal and tumor tissue. Therefore, the student concludes that this gene is not an oncogene. Do you agree with this conclusion? Justify your answer (5-6 senetences max).
Chapter 8 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 8.4 - Two genes associated with breast cancer, BRCA1 and...Ch. 8.4 - Prob. 2GRCh. 8 - What are Bruces options at this point? Bruce and...Ch. 8 - Should he reconsider and try chemotherapy instead?...Ch. 8 - Should he go ahead and enroll on the chance that...Ch. 8 - Until 1944, which cellular component was thought...Ch. 8 - Why do you think nucleic acids were originally not...Ch. 8 - Prob. 3QPCh. 8 - In the experiments of Aery, MacLeod, and McCarty,...Ch. 8 - Read the following experiment and interpret the...
Ch. 8 - Recently, scientists discovered that a rare...Ch. 8 - List the pyrimidine bases, the purine bases, and...Ch. 8 - In analyzing the base composition of a DNA sample,...Ch. 8 - The basic building blocks of nucleic acids are: a....Ch. 8 - Adenine is a: a. nucleoside b. purine c....Ch. 8 - Polynucleotide chains have a 5 and a 3 end. Which...Ch. 8 - DNA contains many hydrogen bonds. Are hydrogen...Ch. 8 - Prob. 13QPCh. 8 - State the properties of the WatsonCrick model of...Ch. 8 - Using Figures 8.7 and 8.9 as a guide, draw a...Ch. 8 - A beginning genetics student is attempting to...Ch. 8 - Chemical analysis shows that a nucleic acid sample...Ch. 8 - Prob. 18QPCh. 8 - RNA is ribonucleic acid, and DNA is...Ch. 8 - What is the function of DNA polymerase? a. It...Ch. 8 - Which of the following statements is not true...Ch. 8 - Make the complementary strand for the following...Ch. 8 - How does DNA replication occur in a precise manner...Ch. 8 - Nucleosomes are complexes of: a. RNA and DNA b....Ch. 8 - Discuss the levels of chromosomal organization...
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- Two genes associated with breast cancer, BRCA1 and BRCA2, were discovered in 1994 and 1995, respectively, and shortly thereafter, were patented by Myriad Genetics, a company based in Utah. Under the patents, testing for mutations in these genes could only be performed by Myriad, at costs from 300 to 3,000. Myriad also patented the process of analyzing the results of such tests, preventing anyone who obtains the sequence of their BRCA genes by other means (which itself would probably be patent infringement) from interpreting the information. The idea that genes can be patented has been a contentious issue from the beginning. Patents are not granted for products of nature, meaning that genes inside the body are not patentable, but biotech companies successfully argued that by removing a gene from the human body, purifying it, and then obtaining its DNA sequence, they created something not found in nature, and which is therefore a patentable invention. The U.S. Patent Office found the argument persuasive, but opponents argue that genes are parts of our bodies and can be identified but not invented. Biotech companies argue that without the protection offered by patents, they would have no incentive for research and development of diagnostic tests. In Europe, patents for BRCA1 and BRCA2 were revoked in 2004 because they did not meet the standards for a patent. After more than a decade of legal disputes, the patents were partially restored in 2008 on a very restricted basis. In the United States, a lawsuit, focused on the patents for the BRCA genes, was filed in May 2009. The suit challenges the basic idea that genes are patentable. In November 2009, the judge ruled that the lawsuit can proceed, and the case is moving forward. In March 2010, a federal court invalidated Myriad Genetics patent on these genes. In August 2011, the U.S. Court of Appeals reversed the lower courts decision and ruled that gene sequences isolated from cells are not a product of nature and are therefore patentable. The case went to the U.S. Supreme Court, which ordered the appeals court to reconsider the case. The Federal Appeals Court did not change its decision, and the case once again, went to the U.S. Supreme Court. A unanimous decision in June 2013 invalidated Myriads patents on the basis that isolating a gene from nature does not make it patentable. This is a landmark decision on gene patenting with widespread ramifications for the biotechnoloogy industry. Will this decision reduce the incentives for companies to invest in new diagnostic tests that would be used by cancer victims or those with serious genetic disorders?arrow_forwardAlthough it is well known that X-rays cause mutations, they are routinely used to diagnose medical problems, including potential tumors, broken bones, and dental cavities. Why is this done? What precautions need to be taken?arrow_forwardA graduate student who has not taken BIOL 519 thinks they have discovered a new oncogene that could cause breast cancer. The student transfects cells with this oncogene and finds that the cells proliferate uncontrollably. The student next designs a PCR assay that will detect the presence of the oncogene in cancerous breast tissue. The student sets up the assay and analyzes the presence of the oncogene in normal and tumor issue samples (See data below). The student is disappointed to see that the potential oncogene is present at similar levels in both the normal and tumor tissue. Therefore, the student concludes that this gene is not an oncogene. Do you agree with this conclusion? Justify your answer (5-6 senetences max). Oncogene? GADPH Normal Tumor 1 Tumor 2 Tumor 3arrow_forward
- Dolly is the first mammal to have been successfully cloned from an adult cell Which of the following statement/s is/are most relevant to the birth of Dolly? I. It suggests that human could be cloned. II. It proves that specialized cells could be used to create an exact copy of the animal they came from. III. It improves the production of milk, meat, and other products from livestock. IV. It proves that animals could be cloned to have gene mutations that help scientists study diseases that develop in the animals. A. II only B. I and II C. III, and IV D. II, III, and IV Which of the following statements best explain the significance of mitosis and ? A. Both mitosis and meiosis produce diploid cells which responsible for the continuity of life. B. Many single-celled organisms rely on mitosis and meiosis as their primary means of asexual reproduction C. replication, cells have another interesting choice, whether they want to make an identical copy, or do they want to make four half-copies…arrow_forwardOf the genes in the microarray shown in the lower part of Figure 20.10, are most overexpressed or underexpressed in tumors from patients that remained cancer free for at least five years? Explain your reasoning.arrow_forwardBacteria can be used to produce human growth hormone (HGH - a peptide/protein) through genetic engineering. The human gene for HGH is inserted into a plasmid, which is then taken up by a bacterial cell, which divides and multiplies into a clone of cells, all of which contain the plasmid with the HGH gene. The bacteria express the HGH gene, producing HGH which can be harvested and used for treatment of humans. (See figure below) Which of the following statements is NOT true about this process? bacterium Vector, such as a DNA containing the gene of plasmid, isolated it from a different species is Gene encoding protein for pest resistance is inserted into plant cells ©2019 Pearson Education, Inc chromosome recombinant DNA (plasmid) transformed bacterium Create and harvest copies of a gene with either of two goals in mind. Gene encoding degradative enzyme to clean up toxdo waste is inserted into bacterial cells ved by an enzyme into gene of interest The desired gene is selected and…arrow_forward
- Answer each of the following questions correctly. a. How PCR may be used for the detection of disease–causing pathogens in a population during COVID Pandemic. For example: It may be used to check if a patient has a COVID virus infection. b. How cloning and expression of certain genes allows for massive production of the desired product. For example: the cloning and expression of insulin in bacteria allows for the mass production of this necessary protein for use by diabetic patients.arrow_forwardScientists carried out a microarray analysis to compare the gene expression of normal liver cells to that of cancer cells from a person with liver cancer. The scientists labeled the cDNA from the normal pancreatic cells with green fluorescent nucleotides. They labeled the cDNA from the cancer cells with red fluorescent nucleotides. The two cDNAs were mixed and allowed to hybridize to a microarray. Normal liver cells =Green Cancer cells =Red The DNA in that spot is the same in cancer cells and normal cells =Yellow Question: Gene alpha is turned on in all liver cells. In the cancer sample there is a nonsense mutation in this gene such that the protein terminates translation early but transcription is unaffected. What color is the alpha gene spot on the microarray? Answer: Yellow please explain why is the answer yellow?arrow_forwardHow can genetic testing help in cancer diagnosis? Briefly explain.arrow_forward
- Herbert Boyer and Stanley Cohen pioneered the technique of DNA cloning allowing genes to be transferred from another biological species easily. Their work also gave rise to the development of different recombinant proteins with therapeutic applications like insulin and growth hormone. The former was cloned using Escherichia coli. coli in 1978. With this breakthrough, the first licensed drug produced using recombinant DNAtechnology was human insulin, developed by Genentech, licensed and marketed by Eli Lilly in 1982. Scientists were able to identify and isolate the gene fragment or the gene of interest, in this case, the gene that is responsible for producing insulin. Moreover, they were able to isolate the bacterial DNA of E. coli. The plasmid and DNA fragment were cut using a restriction enzyme. This DNA fragment was inserted into the plasmid using a DNA ligase. When the DNA fragment was then placed into the bacterial DNA, it was then introduced to the host cell (E. coli) and was then…arrow_forwardWhen doing the virtual DNA microarray analysis, which color (red, green or yellow) would the spot be if that gene was inappropriately inactivated in the cancer cell? When doing the virtual DNA microarray analysis, which color (red, green or yellow) indicated that the cancer cell had an activated a gene that is not normally as active in the non-cancerous version of the cell?arrow_forward5) Below is an image that shows both reproductive and therapeutic cloning. Use this image to answer compare and contrast therapeutic and reproductive cloning. Are they used for similar means…etc. Once you have done that answer the question below. a) There are two types of therapeutic cloning. What are they and how are they different?arrow_forward
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