Campbell Essential Biology (7th Edition)
7th Edition
ISBN: 9780134765037
Author: Eric J. Simon, Jean L. Dickey, Jane B. Reece
Publisher: PEARSON
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Chapter 8, Problem 21BS
Summary Introduction
To explain:
The drugs taxol and vinblastine are discovered in developing areas, but because they are expensive, they primarily benefit people in developed regions, whether an individual sees a conflict in this or not.
Introduction:
Cancer is the uncontrolled growth of cells. This may occur due to the activation of oncogenes or suppression of proto-oncogene. To treat the cancer specialized drugs are made like taxol and vinblastine which inhibit the mitotic spindle that prevents the growth of cells. These two drugs are natural and are often found in developing areas.
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Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell would divide when it is not supposed to, increasing the chance that it would become cancerous. CHOOSE ALL THAT APPLY.
A) A tumor suppressor gene is over-expressed
B) A cyclin gene is mutated so that it is expressed at all times during the cell cycle
C) A cyclin-dependent kinase gene is mutated so that in the Cdk is no longer dependent on its cyclin
D) A Cdk gene is mutated so that the Cdk protein is not made
E) Mutation of an oncogene that causes it to no longer be expressed
F) A proto-oncogene gene is expressed at higher than normal levels
G) The p53 gene is mutated so that no p53 protein is made
Part A and B
A. What below would be likely to lead to cancer development?
A) Overexpression of a cell cycle checkpoint inhibitor
B) Loss of expression of a growth factor that promotes cell cycle entry
C) Overexpression of a receptor tyrosine kinase that promotes cell cycle entry
D) Overexpression of a DNA damage repair enzyme
E) Loss of expression of a regulatory transcription factor that activates transcription of a cyclin
B. Taxols inhibit the proper function of microtubules and are frequently used as chemotherapy drugs. What is the function of microtubules during the cell cycle?
A) They promote the G1 to S checkpoint
B) They normally inhibit M phase from being completed
C) They form the mitotic spindle
E) They mediate DNA replication
F) They form the cleavage furrow during cytokinesis
In the experiment of cell fusion, when tumor cells were fused with normal cells, the initially formed tetraploid cells (or subsequently arising sub-tetraploid cells) were discovered to have lost the ability to form tumors. What is the explanation for this observation?
Chapter 8 Solutions
Campbell Essential Biology (7th Edition)
Ch. 8 - Which of the following is not a function of...Ch. 8 - In what sense are the daughter cells produced by...Ch. 8 - Why is it hard to observe individual chromosomes...Ch. 8 - A biochemist measures the amount of DNA in cells...Ch. 8 - What phases of mitosis are opposite in terms of...Ch. 8 - Complete the following table to compare mitosis...Ch. 8 - If an intestinal cell in a dog contains 78...Ch. 8 - A micrograph of a dividing cell from a mouse shows...Ch. 8 - Prob. 9SQCh. 8 - Prob. 10SQ
Ch. 8 - Although nondisjunction is a random event, there...Ch. 8 - Prob. 12IMTCh. 8 - Prob. 13IMTCh. 8 - For each statement, identify which major theme is...Ch. 8 - A mule is the offspring of a horse and a donkey. A...Ch. 8 - You prepare a slide with a thin slice of an onion...Ch. 8 - Interpreting Data The graph shows the incidence of...Ch. 8 - If an endangered species can reproduce by...Ch. 8 - Every year, about a million Americans are...Ch. 8 - The practice of buying and selling gametes,...Ch. 8 - Prob. 21BS
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