Inquiry Into Life (16th Edition)
16th Edition
ISBN: 9781260231700
Author: Sylvia S. Mader, Michael Windelspecht
Publisher: McGraw Hill Education
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Chapter 7.4, Problem 2QTC
While Figure 7B does not indicate the need for water, it is an important component of our diet. Where would water interact with these pathways?
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Consider a hypothetical metabolic pathway involving four enzymes to convert molecule A into molecule E:
Enz, E
Enz 1
Enz 2
Enz 3
A
1) A
O2) B
Which molecule is most likely to be a feedback inhibitor that, when present in high concentrations, will reduce the flow of material
through the pathway?
3) C
04) D
B
05) E
C
D
6) none of these
The activity of an allosteric enzyme will be greatest when
1) the pH is optimal for the enzyme.
2) most of the enzyme molecules are in the R conformation.
3) most of the enzyme molecules are in the T conformation.
4) there are equal numbers of enzyme molecules in the R and T conformations.
puiss
What will be the effect on the structure of an allosteric enzyme if a negative allosteric effector is added to a solution of the enzyme?
1) There will be a shift in the equilibrium between the R and T forms; the amount of T will increase.
2) There will be a shift in the equilibrium between the R and T forms; the amount of R will increase.
3) The enzyme will be…
What is the advantage of using ATP as a common energy source?Another way of asking this question is, “Why does ATP provide anadvantage over using a bunch of different food molecules?” For example,instead of just having a Na+/K+-ATPase in a cell, why not have manydifferent ion pumps, each driven by a different food molecule, like aNa+/K+-glucosase (a pump that uses glucose), a Na+/K+-sucrase (a pumpthat uses sucrose), a Na+/K+-fatty acidase (a pump that uses fatty acids),and so on?
Figure 7.11 Dinitrophenol (DNP) is an "uncoupler"
that makes the inner mitochondrial membrane
"leaky" to protons. It was used until 1938 as a weight-
loss drug. What effect would you expect DNP to have
on the change in pH across the inner mitochondrial
membrane? Why do you think this might be an
effective weight-loss drug?
Intermembrane
space
Mitochondrial
matrix
ATP Synthase
ADP
Inner mitochondrial
membrane
ATP
Figure 7.11 ATP synthase is a complex, molecular machine that uses a proton (H) gradient to form ATP from
ADP and inorganic phosphate (Pi). (Credit: modification of work by Klaus Hoffmeier)
Chapter 7 Solutions
Inquiry Into Life (16th Edition)
Ch. 7.1 - Describe the overall equation for cellular...Ch. 7.1 - Prob. 2LOCh. 7.1 - Prob. 3LOCh. 7.1 - Explain the role of NAD+ and FAD in cellular...Ch. 7.1 - Distinguish between the aerobic and anaerobic...Ch. 7.1 - Prob. 3CYPCh. 7.2 - Describe the location and inputs and outputs of...Ch. 7.2 - Explain why ATP is both an input and output of...Ch. 7.2 - Explain why there is an energy-investment phase...Ch. 7.2 - Prob. 2CYP
Ch. 7.3 - Explain how ATP can continue to be produced in the...Ch. 7.3 - Describe the advantages and disadvantages of...Ch. 7.3 - Prob. 1QTCCh. 7.3 - Explain how fermentation acts as a NAD+ recycling...Ch. 7.3 - Describe the environmental conditions that would...Ch. 7.3 - Prob. 2CYPCh. 7.4 - Prob. 1LOCh. 7.4 - Summarize the inputs and outputs of the...Ch. 7.4 - Prob. 3LOCh. 7.4 - How might a meal of a cheeseburger and fries be...Ch. 7.4 - While Figure 7B does not indicate the need for...Ch. 7.4 - Prob. 1CYPCh. 7.4 - Prob. 2CYPCh. 7.4 - Discuss why there is variation in the number of...Ch. 7 - Prob. S2.5BYBCh. 7 - Prob. S3.3BYBCh. 7 - Figure 6.3 How does the ATP cycle resemble a...Ch. 7 - Prob. 1ACh. 7 - Prob. 2ACh. 7 - Prob. 3ACh. 7 - Prob. 4ACh. 7 - Prob. 5ACh. 7 - 6. During glycolysis, what is the net production...Ch. 7 - Prob. 7ACh. 7 - Prob. 8ACh. 7 - Prob. 9ACh. 7 - Prob. 10ACh. 7 - Which of these is not true of the citric acid...Ch. 7 - Which of these is not true of the electron...Ch. 7 - The oxygen required by cellular respiration is...Ch. 7 - Prob. 1TCCh. 7 - Rotenone is a broad-spectrum insecticide that...Ch. 7 - Some fat-burning compounds accelerate the movement...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The following diagram shows the biosynthesis of B12 coenzymes, starting with the vitamin. DMB is dimethylbenzimidazole. (a) What one additional substrate or cofactor is required by enzyme B?(b) Genetic deficiency in animals of enzyme C would result in excessiveurinary excretion of what compound?(c) Some forms of the condition described in (b) can be successfully treatedby injection of rather massive doses of vitamin B12. What kind ofgenetic alteration in the enzyme would be consistent with this result?(d) Genetic deficiency in animals of enzyme B will result in excessive urinaryexcretion of what amino acid?arrow_forwardWhy is diaeehea a symptom of lactose intolerance? 1-Undigested lactose converts into H20 in the digestive tract via enzymatic reactions, resulting in watery feces. 2-Your nervous system detects the lactose and stimulates your bladder to release fluids to your digestive tract. 3-Bacteria in your gut releases toxins in response to the lactose. 4-Undigested lactose sugars creates a large osmotic gradient for water, which pulls water into the digestive tract.arrow_forward1. Shown below is a metabolic pathway: Es E E4 E1 E2 A - B - C - D E3 E6 Q- R – S E7 Es Suppose we have too much of "S" in the cell, please answer the following questions, with regards to feedback inhibition: a) Which enzyme is most likely to be regulated? b) Which substance will act as the 'regulator'? c) Name the "site" where this 'regulator' will bind to the enzyme: d) Is this substance (from #b), a homotropic or heterotropic modulator?arrow_forward
- There are many metabolic pathways in a biological system, and it is critical to regulate these pathways so that only particular pathways are active at a single time. Which enzyme would be in the regulation point in the hypothetical pathway shown below. A¹B 2C 3 D4E A) A → B B) B-C C) C-D D) D→ E E) The regulation point is highly dependent upon the metabolic pathway.arrow_forwardWhich of the following statements is FALSE regarding oxidative phosphorylation? The pH is higher in the matrix relative to that in the inter-membrane space. A large positive difference in reduction potential is associated with a small negative free energy change. Electrons from FADH2 enter at complex II because the reduction potential of FADH2 is greater than that of redox centers in complex I. Oxidation and phosphorylation are coupled via a proton gradient.arrow_forwardCells use primarily two ways of storing potential energy: 1) as concentration gradients and 2) in molecules. A) Explain how energy can be stored in these two forms and how it can be used to do other work. B) Propose an analogy that can explain each of these forms of energy storage using everyday items.arrow_forward
- What would be the effect on ATP production during chemiosmosis and oxidative phorphorylation, if the pH within the inner membrane space of the mitochondrion were decreased, assuming no effect of pH on the structure of proteins in the membrane? a) it would increase b) it would decrease c)it would stay the samearrow_forwardDrugs are small molecules that often occur in either a neutral or a charged form, depending on pH. For example, aspirin can be either neutral or lose a proton to be negatively charged. When aspirin is charged, it does not diffuse well into the body. pH varies in the gastrointestinal track. Since the stomach has a low pH (pH=3), it has a larger concentration of neutral aspirin (10-3 M), while the small intestine (pH=6) has a smaller neutral aspirin concentration (10-6 M). For the following, assume that the neutrally charged aspirin molecule has a diffusion coefficient through the cell of 1 x 10-6 cm2/s.arrow_forwardDrugs are small molecules that often occur in either a neutral or a charged form, depending on pH. For example, aspirin can be either neutral or lose a proton to be negatively charged. When aspirin is charged, it does not diffuse well into the body. pH varies in the gastrointestinal track. Since the stomach has a low pH (pH=3), it has a larger concentration of neutral aspirin (10-3 M), while the small intestine (pH=6) has a smaller neutral aspirin concentration (10-6 M). For the following, assume that the neutrally charged aspirin molecule has a diffusion coefficient through the cell of 1 x 10-6 cm2/s. C) We’d like to figure out where in the body aspirin is absorbed as determined by its diffusion rate. If the small intestine has a surface area 50 times that of the stomach, what is the ratio of the diffusion rates in the stomach compared to the small intestine? D) In which part of the GI tract is most of the aspirin absorbed?arrow_forward
- Is it likely that any metabolic pathway can exist without control mechanisms?arrow_forwardCells use two ways of storing potential energy: 1) as concetration gradients and 2) in molecules. A) Explain how energy can be stored in these two forms and how it can be used to do the work. B) Propose an analogy that can explain each these forms of energy storage using everyday items.arrow_forwardWhich out of the following statements is true about the regulation of metabolic pathway? a) Most of the metabolic pathways are regulated b) Most of the metabolic pathways are not regulated c) Regulation of metabolic pathways always involves changing the amount of enzymes d) Metabolic regulation always depends on control by hormonesarrow_forward
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