Organic Chemistry (6th Edition)
Organic Chemistry (6th Edition)
6th Edition
ISBN: 9781260119107
Author: Janice Gorzynski Smith
Publisher: McGraw Hill Education
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Chapter 7, Problem 51P
Interpretation Introduction

Interpretation: An explanation corresponding to the statement that the amine N atom is more nucleophilic than the amide N atom in CH3CONHCH2CH2CH2NHCH3 is to be stated.

Concept introduction: The replacement or substitution of one functional group with another different functional group in any chemical reaction is termed as substitution reaction. The electron rich chemical species that contains negative charge or lone pair of electrons are known as a nucleophile. In a nucleophilic substitution reaction, nucleophile takes the position of leaving group by attacking the electron deficient carbon atom.

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The structure of Synthroid, used to treat hypothyroidism (low-functioning thyroid), is shown below. Highlight the phenol, the ether, the amine, and the carboxylic acid. Is the carboxylic acid in its neutral or ionic form? Is the amine in its neutral or ionic form? он OH Synthroid
Why is the amine N atom more nucleophilic than the amide N atom in CH,CONHCH,CH,CH,NHCH,?
2. Below is the structure of caffeine. Circle and label (a) an amide functional group, (b) a tertiary amine, and (c) the purine ring system. O CH3 N CH-N O N CH3 N H 3. Caffeine is an alkaloid and has base characteristics. Of the four nitrogens in the structure of the molecule, which one(s) would give it this property? sneltro bem 4. Besides caffeine, what else is extracted into the tea? Why can you use the basic salt, Na₂CO3, sodium carbonate, to remove this material? 5. What criterion is used for the purity of a sample of caffeine?

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Organic Chemistry (6th Edition)

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