Human Biology: Concepts and Current Issues (8th Edition)
8th Edition
ISBN: 9780134042435
Author: Michael D. Johnson
Publisher: PEARSON
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Chapter 7, Problem 4AWK
Summary Introduction
To review:
The variable responsible for lowering the pH level in metabolically active cells that causes the release of oxygen from the red blood cells (RBCs).
Introduction:
RBC is the cellular component of blood, which is responsible for carrying oxygen from lungs and supplies it to the body cells. Oxygen is the key ingredient that is required for the
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Chapter 7 Solutions
Human Biology: Concepts and Current Issues (8th Edition)
Ch. 7 - Prob. 1QCCh. 7 - Prob. 2QCCh. 7 - Describe the functions of blood.Ch. 7 - Prob. 2CRCh. 7 - Explain how the production of red blood cells is...Ch. 7 - Prob. 4CRCh. 7 - Prob. 5CRCh. 7 - Prob. 6CRCh. 7 -
7. Describe the mechanism of hemostasis.
Ch. 7 - Prob. 8CR
Ch. 7 - Prob. 9CRCh. 7 - Prob. 10CRCh. 7 - Prob. 1TYCh. 7 - Prob. 2TYCh. 7 - Prob. 3TYCh. 7 - Prob. 4TYCh. 7 - Prob. 5TYCh. 7 -
6. A person with Type A- (A-negative) blood will...Ch. 7 - Prob. 7TYCh. 7 - Prob. 8TYCh. 7 - Prob. 9TYCh. 7 - Prob. 10TYCh. 7 -
11. Which white blood cells are present in the...Ch. 7 - Prob. 12TYCh. 7 - Prob. 13TYCh. 7 - Prob. 14TYCh. 7 - Prob. 15TYCh. 7 - Prob. 1AWKCh. 7 - Prob. 2AWKCh. 7 - Prob. 3AWKCh. 7 - Prob. 4AWKCh. 7 - Prob. 5AWKCh. 7 -
6. Coumadin is an anticoagulant drug that is...
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- Hemoglobin can exist in one of two forms. What are they?arrow_forwardAnswer the following questions about hemoglobin. The number of high affinity binding sites in the R form of hemoglobin is .The number of low affinity binding sites in the R form of hemoglobin is .The number of O2 molecules that need to bind to convert hemoglobin from the T to R form is .The number of high affinity binding sites in the T form of hemoglobin is .The number of low affinity binding sites in the T form of hemoglobin isarrow_forwardWhich one of the following statements concerning Hb (hemoglobin) A1c is CORRECT? Question 4 options: a) HbA1c contains glucose molecules b) The concentration of HbA1c in the red blood cells (RBCs) decreases as RBCs age in the circulation c) Insulin injection can decrease the amount of HbA1c in the blood d) Weight is correlated with HbA1c concentrationarrow_forward
- In addition to O2 binding, changes in other chemical conditions can result in changes in hemoglobin structure and function. Increases in blood H+ result in oxygen binding curves for hemoglobin that are shifted to the right. The effect of H+ can be understood in terms of the equilibrium:H-Hb+ + O2 → Hb-O2 + H+How does the difference in pH in the lungs and tissues help hemoglobin do its job of delivering oxygen? Use the equilibrium equation in your argument.arrow_forwardYou are studying with a friend who is describing the Bohr effect. She tells you that in the lungs, hemoglobin binds oxygen and releases hydrogen ion; as a result, the pH increases. She goes on to say that in actively metabolizing muscle tissue, hemoglobin releases oxygen and binds hydrogen ion and, as a result, the pH decreases. Do you agree with her reasoning? Why or why not?arrow_forwarda) Hemoglobin accounts for 95% of the protein in red blood cells. If you Google the number of hemoglobin molecules in a RBC, most sources state 250-270 million hemoglobin molecules. If hemoglobin has a molecular weight of 67,000 Da, what is the concentration of hemoglobin in RBCs? Show your work and show your units. Use dimensional analysis to have your final answer in moles per liter. B) The hemoglobin molecule is nearly spherical with a diameter of 55 Angstroms. You can look at the 3D structure of human hemoglobin on the RCSB PDB website. Calculate the volume of a hemoglobin molecule, and can the number of hemoglobin molecules quoted in Question a actually fit into one red blood cell?arrow_forward
- I am eating a snack as I type this question. My body is breaking down the food to provide energy so that my muscles will continue to contract and I can continue to type. During this process, some acidic byproduct could be produced, decreasing the the pH in my muscles. a) What effect will this have on the structure of hemoglobin. (Briefly describe. No more than 2-3 sentences.) b) What effect does this have on the Pso of hemoglobin?arrow_forwardHemoglobin will bind oxygen and release CO2 in places where there is a higher concentration of O2, lower concentration of CO2, lower temperature and lower acidity (as it is in lungs) and will do the reverse – release oxygen and bind CO2 - in places where there is a lower concentration of O2, higher concentration of CO2, higher temperature and higher acidity (as it is in working muscles). True False While white blood cells never leave the circulation, red blood cells regularly leave it and travel by lymphatic system or find home in other tissues, e.g., lymph nodes, spleen, etc. True False Blood clotting (coagulation) is a complex process involving many factors and it exhibits positive feedback loops: many of the factors also stimulate production of their own precursors. B lymphocytes mature in the thymus while T lymphocytes mature in the bone marrow True False Antibodies are molecules on the surfaces of foreign…arrow_forwardAccording to Figure 17.10b, at a pH of 7.4, how much hemoglobin is unloaded in the tissue? 12% 24% 56% 72% 95%arrow_forward
- Select the hemoglobin variant(s) that are described by each statement. (a) The variant least likely to cause pathological symptoms. (b) The variant(s) likely to show pl values different from that of HbA on an isoelectric focusing gel. (c) The variant most likely to show a decrease in BPG binding and an increase in the overall affinity of the hemoglobin for oxygen. Answer Bank Hb Milwaukee Hb Cowtown Hb Memphis Hb Philly Hb Providence Hb Bibba HbSarrow_forwardCarbon monoxide (CO) is a colourless, odourless gas that result from the burning of hydrocarbons, such as in a poorly functioning furnace or vehicle emissions. CO can bind with hemoglobin to form carboxyhemoglobin. Hemoglobin's affinity for CO is 200 times greater than its affinity for oxygen. The initial symptoms of carbon monoxide poisoning are flu-like, such as dizziness, headache and vomiting. However, when left unchecked, CO poisoning can result in unconsciousness, loss of blood flow to the vital organs and, eventually, death. (Source: Bleecker, M.L. (2015). Carbon Monoxide Intoxication. Handbook of Clinical Neurology. Elsevier B.V.) 5. Name the gases normally carried by hemoglobin in the body. Using your knowledge of the circulatory and respiratory systems, provide a possible explanation for the symptoms of carbon monoxide poisoning.arrow_forwardCan all abnormal hemoglobin be diagnosed by electrophoresis ?Explain why or why not .arrow_forward
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