Biology
Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 6, Problem 2CQ
Summary Introduction

To determine: The mechanism and purpose of feedback inhibition in a metabolic pathway.

Introduction: Cells regulate the overproduction or underproduction of components within the system. Regulatory processes help the cells to check the unnecessary generation of substances inside the cell and also prevent the expenditure of unwanted energy in doing such activities. Feedback inhibition is one of the types of such regulatory processes.

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Distinguish between competitive and noncompetitive allosteric feedback inhibition.
Many biosynthetic pathways are regulated by feedback control, where the product of a pathway turns off an enzyme that catalyzes an early step in the pathway. Usually, this control comes from an allosteric interaction. Of the types of reversible enzyme inhibition (Competitive inhibition, Noncompetitive inhibition, and Uncompetitive inhibition), what type is most likely to occur in a feedback control mechanism like this and why?
How can enzyme inhibition be used in the treatment of certain diseases? Cite examples.
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