Microbiology with Diseases by Taxonomy (5th Edition)
5th Edition
ISBN: 9780134019192
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 5, Problem 6TMW
Summary Introduction
To determine:
The reason that feedback inhibition is necessary for controlling anabolic pathways.
Introduction:
The feedback given by the end product of an enzyme is known as feedback inhibition. It may be negative or may be positive. The anabolism is the mechanism in which two small size and simple molecules combine to form large and complex molecules.
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Inhibitors of acetylcholinesterase, such as edrophonium, are used to treat Alzheimer’s disease. The substrate for acetylcholinesterase is acetylcholine. Structures are attached.
What kind of inhibitor is edrophonium? Explain.
Can inhibition by edrophonium be overcome in vitro by increasing the substrate concentration? Explain.
Does this inhibitor bind reversibly or irreversibly to the enzyme? Explain.
What are the cellular advantages to feedback inhibition?
What is the significance of the fact that regulatory enzymes often are located at pathway branch points? What are isoenzymes, and why are they important in pathway regulation?
Chapter 5 Solutions
Microbiology with Diseases by Taxonomy (5th Edition)
Ch. 5 - Prob. 1MCCh. 5 - Prob. 2MCCh. 5 - Prob. 3MCCh. 5 - Prob. 4MCCh. 5 - Prob. 5MCCh. 5 - Prob. 6MCCh. 5 - Prob. 7MCCh. 5 - Prob. 8MCCh. 5 - Prob. 9MCCh. 5 - Prob. 10MC
Ch. 5 - Prob. 11MCCh. 5 - Prob. 12MCCh. 5 - Prob. 13MCCh. 5 - Prob. 14MCCh. 5 - Prob. 15MCCh. 5 - Prob. 16MCCh. 5 - Prob. 17MCCh. 5 - Prob. 18MCCh. 5 - Prob. 19MCCh. 5 - Prob. 20MCCh. 5 - Prob. 1MCh. 5 - Prob. 1FIBCh. 5 - Prob. 2FIBCh. 5 - Prob. 3FIBCh. 5 - Prob. 4FIBCh. 5 - Prob. 5FIBCh. 5 - Prob. 6FIBCh. 5 - Prob. 7FIBCh. 5 - Prob. 8FIBCh. 5 - Prob. 9FIBCh. 5 - Prob. 10FIBCh. 5 - Label the mitochondrion to indicate the location...Ch. 5 - Label the diagram below to indicate acetyl-CoA,...Ch. 5 - Examine the biosynthetic pathway for the...Ch. 5 - Prob. 1SACh. 5 - Prob. 2SACh. 5 - Prob. 3SACh. 5 - Prob. 4SACh. 5 - Prob. 5SACh. 5 - Prob. 6SACh. 5 - Prob. 7SACh. 5 - Prob. 8SACh. 5 - Prob. 9SACh. 5 - Prob. 10SACh. 5 - Prob. 11SACh. 5 - Prob. 12SACh. 5 - Prob. 13SACh. 5 - Prob. 14SACh. 5 - A laboratory scientist notices that a cer1ain...Ch. 5 - Arsenic is a poison that exists in two states in...Ch. 5 - Explain why an excess of all three of the amino...Ch. 5 - Prob. 3CTCh. 5 - Describe how bacterial fermentation causes milk to...Ch. 5 - Giardia intestinalis and Entamoeba histolytica are...Ch. 5 - Prob. 6CTCh. 5 - Prob. 7CTCh. 5 - Prob. 8CTCh. 5 - Cyanide is a potent poison because it irreversibly...Ch. 5 - How are photophosphorylation and oxidative...Ch. 5 - Prob. 11CTCh. 5 - Compare and contrast aerobic respiration,...Ch. 5 - Scientists estimate that up to one-third of Earths...Ch. 5 - Prob. 14CTCh. 5 - Prob. 15CTCh. 5 - Some desert rodents rarely have water to drink....Ch. 5 - Prob. 17CTCh. 5 - Prob. 18CTCh. 5 - Explain why hyperthermophiles do not cause disease...Ch. 5 - In addition to extremes in temperature and pH,...Ch. 5 - Prob. 21CTCh. 5 - Prob. 22CTCh. 5 - Prob. 23CTCh. 5 - Prob. 24CTCh. 5 - Prob. 25CTCh. 5 - A scientist moves a green plant grown in sunlight...Ch. 5 - What class of enzyme is involved in amination...Ch. 5 - Prob. 1CMCh. 5 - How can oxidation take place in an anaerobic...Ch. 5 - Prob. 2TMWCh. 5 - Prob. 3TMWCh. 5 - Prob. 4TMWCh. 5 - Prob. 5TMWCh. 5 - Prob. 6TMW
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Identify the following statements as true or false. If a statement is false, explain what is wrong with that statement a) Transition state analogs bind very tightly with the enzyme active site as they form covalent bonds with the active site b) Receptor desensitization happens upon prolonged exposure of receptors to both agonists and antagonists c) Dactinomycin and Doxorubicin are examples of drugs that bind with the major groove of DNA d) Mitomycin C forms interstrand crosslinking while cisplatin forms intrastrand crosslinking of DNAarrow_forwardHow does the interaction between allosteric and covalent modulation result?arrow_forwardwhy is non-competitive inhibiton a special type of mixed inhibiton?arrow_forward
- Different Types of Regulation require by Catabolic and Anabolic Pathways?arrow_forwardWhy is Methotrexate used in chemotherapy? How does it work in terms of enzyme inhibition that is involved in its mechanism action?arrow_forwardWhat is the major activator (non-allosteric, direct-activator) of phosphorylase? How does this activator activate phosphorylase (type of regulation)?arrow_forward
- Does the behavior of allosteric enzymes become more or less cooperative in the presence of inhibitors?arrow_forwardCorticosteroids (a type of hormone), and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are non-narcotic pain relievers. Both medications are prescribed to reduce inflammation in the body. NSAIDs such as aspirin, acetaminophen, and ibuprofen are able to reduce pain, fever, and inflammation by blocking the action of the cyclooxygenase enzyme (COX) that catalyzes the conversion of arachidonic acid into prostaglandins. Common corticosteroids include prednisone, cortisone, and methylprednisolone. Choose one of these three corticosteroids. The corticosteroid that you choose and then explain how the drug works to reduce inflammation.arrow_forwardCorticosteroids (a type of hormone), and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are non-narcotic pain relievers. Both medications are prescribed to reduce inflammation in the body. NSAIDs such as aspirin, acetaminophen, and ibuprofen are able to reduce pain, fever, and inflammation by blocking the action of the cyclooxygenase enzyme (COX) that catalyzes the conversion of arachidonic acid into prostaglandins. Common corticosteroids include prednisone, cortisone, and methylprednisolone. Choose one of these three corticosteroids. Do some internet research on the corticosteroid that you choose and then explain how the drug works to reduce inflammation.arrow_forward
- Draw a mechanism using the general features of a serine protease to explain how inhibitor x might work using the following information: inhibitor x is a representative of a new family of serine protease inhibitors. treatment of chymotrypsin with inhibitor X rapidly decreased activity. to determine the mode of inhibition the researchers used dialysis to exchange the buffer with buffer lacking free inhibitor x. after dialysis, the enzyme did NOT recover any activity.arrow_forwardThe nerve gas sarin acts as a poison by covalently bonding to a hydroxyl group in the active site of the enzyme acetylcholinesterase. This binding results in a higher-than-normal amount of acetylcholine at a nerve synapse, resulting in muscle spasms. From this description, would you expect sarin to be a competitive, noncompetitive, or irreversible inhibitor? noncompetitive inhibitor irreversible inhibitor competitive inhibitorarrow_forwardHow can you decrease (or stop) the rate of binding for a noncompetitive inhibitor? Could you change the receptor allosteric sites to prevent noncompetitive binding?arrow_forward
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