Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Question
Chapter 47.1, Problem 4R
Summary Introduction
To review:
The reason behind severe muscle paralysis on accidental exposure to Malathion, which degrades acetylcholinesterase enzyme.
Introduction:
The Malathion is an organophosphate, which is used as a pesticide in agriculture to control the pest. It is known as maldison in Australia and New Zealand. In many countries, it is used on a large scale to control pests like Nile virus and Mediterranean fruit fly.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
When the neurotransmitter acetylcholine (ACh) binds the acetylcholine receptor (a GPCR) on muscle cells, it causes them to contract. ZIGGY, a chemical analog of ACh, also binds to the same acetylcholine receptor on muscle cells, but instead causes the muscle cells to relax. For this reason, it is sometimes prescribed as a muscle relaxer. Explain in 3-4 sentences how ZIGGY could cause muscle relaxation.
How can both ZIGGY and ACh bind the same GPCR? And then how can they have different effects on the cells, despite binding to the same receptor on the same cells?
Botulinum toxin (Botox) works by blocking the exocytosis of acetylcholine. A number of different medical and cosmetic procedures use this chemical. Injection of small quantities of botulinum toxin (Botox) into specific overactive muscles causes muscle relaxation that smooths the skin and reduces wrinkles. Injection into certain spinal ganglia helps reduce a certain form of chronic pain, and injections into the salivary glands causes the reduction of overactive saliva production.
What type of toxin is Botox?
Agonist
or
Antagonist
Botulinum toxin (Botox) works by blocking the exocytosis of acetylcholine. A number of different medical and cosmetic procedures use this chemical. Injection of small quantities of botulinum toxin (Botox) into specific overactive muscles causes muscle relaxation that smooths the skin and reduces wrinkles. Injection into certain spinal ganglia helps reduce a certain form of chronic pain, and injections into the salivary glands causes the reduction of overactive saliva production.
What type of toxin is Botox?
a. Agonist
b. Antagonist
Chapter 47 Solutions
Life: The Science of Biology
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following statements regarding the motor end plate in the somatic motor division of the nervous system is true? After the activation of voltage-gated calcium channels, the neuron releases ACh onto the muscarinic receptors on the surface of the highly folded area of the muscle fibre. The preganglionic nerve fibre releases ACh onto the postganglionic nerve fibre, which then releases ACh onto the cholinergic receptors of the motor end plate. Chemically gated monovalent cation channels on the motor end plate are activated once the motor neuron releases ACh onto the nicotinic receptors on the surface of the muscle cell. The AChE enzyme enhances the amount of ACh released into the neuromuscular junctionarrow_forwardare these True or False? Receptors on the post-synaptic cell membrane that bind the acetylcholine are voltage-gated channels (channels that open in response to a change in the electrical charge of the membrane). When a muscle cell is not contracting its cell membrane is negative on the inner surface. The effect of a neurotransmitter on the muscle cell membrane is to modify its ion permeability properties temporarily.arrow_forwardSpastic paralysis (resulting from the failure of muscles to relax), induced by the neurotoxin strychnine, occurs when this poison blocks the binding of: the excitatory neurotransmitter acetylcholine to post-synaptic sodium channels the excitatory neurotransmitter glutamate to post-synaptic calcium channels the excitatory neurotransmitter serotonin to post-synaptic potassium channels the inhibitory neurotransmitter glycine to post-synaptic chloride channels the inhibitory neurotransmitter melatonin to post-synaptic bicarbonate channelsarrow_forward
- One treatment for myasthenia gravis is a medication that blocks the activity of acetylcholinesterase. Suggest why this might be a successful treatment.arrow_forwardPut the following events in chronological order. (Some of the steps may be missing.)1) Ca*+ floods into the pre-synaptic neuron.2) ch (Acetylcholine) binds to ACh receptors in the sarcolemma.3) Na+ floods into the post-synaptic muscle cell.4) The A.P arrives at the pre-synaptic terminal causing Ca+ channels to open.5) Ach from the synaptic vesicles spills into the pre-synaptic cleft.6) A post-synaptic action potential results in the muscle fiber (depolarizationarrow_forwardone treatment for myasthenia gravis is a medication that blocks the activity of acetylcholinesteras. suggest why this might be a succesful treatmentarrow_forward
- Which of the following structures has activity like acetylcholine? HyC H-C HC NMeg NMey D]arrow_forwardAre these true or false? Acetylcholine molecules are actively transported from the axon to their receptors on the muscle membrane by special transport proteins. Receptors on the post-synaptic cell membrane that bind the acetylcholine are voltage-gated channels (channels that open in response to a change in the electrical charge of the membrane). When a muscle cell is not contracting its cell membrane is negative on the inner surface. The effect of a neurotransmitter on the muscle cell membrane is to modify its ion permeability properties temporarily. During depolarization, a small region of the muscle cell's membrane becomes less negative on the inside." Both sodium and potassium are more concentrated in the extracellular fluid than the intracellular fluid. After an action potential passes over a region of the sarcolemma the region remains positively charged throughout the entire muscle contraction. An increase in the calcium ion level in the cytosol causes thin filaments to begin…arrow_forwardThe neurotransmitter released by the presynaptic membrane (axon knob) for skeletal muscle contraction is always: Dopamine. Norepinephrine. Acetylcholine. None of the above.arrow_forward
- Students in a veterinary school are given the following hypotheticalproblem: A dog ingests organophosphate poison, and the students areresponsible for saving the animal’s life. Organophosphate poisons bindto and inhibit acetylcholinesterase. Several substances the studentscould inject include the following: acetylcholine, curare (which blocksacetylcholine receptors), and potassium chloride. If you were a studentin the class, what would you advise to save the animal?arrow_forwardA patient has been exposed to the organophosphate pesticide malathion,which inactivates acetylcholinesterase. Which of the following symptoms would you predict: blurring of vision, excess tear formation, frequent or involuntary urination, pallor (pale skin), muscle twitching, orcramps? Would atropine be an effective drug to treat the symptoms?(See Clinical Impact 16.2 for the action of atropine.) Explain.arrow_forwardIn muscles, acetylcholine is released by the _________________________and opens specific channels that allow the ion ______ to depolarize the membrane. motor neuron, sodium motor neuron, potassium muscle fibril, sodium muscle fibril, potassiumarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Basic Clinical Lab Competencies for Respiratory C...NursingISBN:9781285244662Author:WhitePublisher:CengageHuman Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage LearningMedical Terminology for Health Professions, Spira...Health & NutritionISBN:9781305634350Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. SchroederPublisher:Cengage Learning
Basic Clinical Lab Competencies for Respiratory C...
Nursing
ISBN:9781285244662
Author:White
Publisher:Cengage
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Medical Terminology for Health Professions, Spira...
Health & Nutrition
ISBN:9781305634350
Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:Cengage Learning
Nervous System - Get to know our nervous system a bit closer, how does it works? | Neurology; Author: FreeMedEducation;https://www.youtube.com/watch?v=6O-0CVAgaEM;License: Standard youtube license