Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 43, Problem 5Q
Summary Introduction
To review:
The mechanism by which variants of folate receptor alpha could affect the frequency of neural tube defects during pregnancy.
Introduction:
Folic acid or folate is essential for the closure of neural tube in the developing fetus. The condition, in which the neural tube does not close, can lead to serious birth defects in the newborn child, making it almost impossible for the child to survive.
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Progesterone is a steroid hormone that is produced by the placenta during pregnancy. Based on its structure (shown below), explain why progesterone’s effects are mediated by a receptor located inside the cell rather than on the cell membrane.
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The melatonin receptor exists in different isoforms: MT1, encoded by MT-1 gene and MT2, encoded by MT-2
gene.
The following is the sequence corresponding to 90-140 base pairs (bp) of MT-1 and MT-2 genes.
Which of the following statements are true for these DNA sequences. Select all that apply.
90
140
MT-1: 5'------GATATGCCCCCCCCGGCGCGCGATATGCCCCCCCCGGCGCGCGTGCGTGA
-3'
3'------CTATACGGGGGGGGCCGCGCGCTATACGGGGGGGGCCGCGCGCACGCACT-
-5'
90
140
---GATATGATATATATATATATAGATATGAAAAATTTTTATATAGTGCGTGA-
MT-2: 5'
---3'
3'-----CTATACTATATATATATATATCTATACTTTTTAAAAAATTATCACGCACT--
----5'
MT-2 will denature at a higher temperature than MT-1
1 MT-2 will denature at a lower temperature than MT-1
MT-1 will denature at a higher temperature than MT-2
MT-1 will denature at a lower temperature than MT-2
Chapter 43 Solutions
Life: The Science of Biology
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