Biology
12th Edition
ISBN: 9780134813448
Author: Audesirk, Teresa, Gerald, Byers, Bruce E.
Publisher: Pearson,
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Chapter 42.3, Problem 1CT
In 2017, scientists used CRISPR Cas9 DNA editing to repair a defective gene in a human embryo. Should this be allowed? Is preventing disease and disability in the children sufficient justification for changing the genetic makeup of a human being? What about “designer” children whose DNA may be changed solely to produce an athlete or supermodel body type?
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The first attempts at gene therapy began in 1990 with the treatment of a young girl with a genetic disorder abbreviated SCID. What does SCID stand for? In the context of SCID, what does ADA stand for?
1) A mutation is a change that occurs in our DNA sequence, either due to mistakes when the DNA is copied or as the result of environmental factors. All BUT ONE of the statements below correctly describes or explains genetic mutations.
A) Mutation can disrupt normal cell activity and cause diseases, like cancer.
B) Mutations in parents' cells are then passed down to offspring via reproduction.
C) Our cells can recognise any potentially mutation-causing damage and repair it before it permanent.
D) Mutations can occur as the result of exposure to environmental factors such as smoking, toxins and radiation.
CRISPR techniques allow scientists to modify specific genes while sparing all others, thus clarifying the association between a given gene and its consequence to the organism. If this technology can change the future of Medicine, what specific benefits CRISPR can bring to genetic testing or analysis? How can CRISPR help to enhance gene therapy or treatment of genetic diseases?
Chapter 42 Solutions
Biology
Ch. 42.1 - Prob. 1TCCh. 42.1 - Prob. 2TCCh. 42.1 - Prob. 1CSCCh. 42.1 - Prob. 1CYLCh. 42.1 - Prob. 2CYLCh. 42.1 - Prob. 3CYLCh. 42.2 - Mammalian sperm dont live very long after...Ch. 42.2 - Prob. 1TCCh. 42.2 - Prob. 1HYEWCh. 42.2 - describe the human male and female reproductive...
Ch. 42.2 - explain how hormonal interactons control...Ch. 42.2 - describe spermatogenesis and oogenesis, the...Ch. 42.3 - In 2017, scientists used CRISPR Cas9 DNA editing...Ch. 42.3 - describe the principal methods of contraception,...Ch. 42.3 - Prob. 2CTCh. 42 - In humans, sperm are produced in the a....Ch. 42 - In humans, fertilization usually occurs in the a....Ch. 42 - Prob. 3MCCh. 42 - Prob. 4MCCh. 42 - Prob. 5MCCh. 42 - Reproduction by a single animal, without the need...Ch. 42 - In mammals, the male gonad is called...Ch. 42 - Prob. 3FIBCh. 42 - Prob. 4FIBCh. 42 - Prob. 5FIBCh. 42 - Oocytes develop in a multicellular structure, the...Ch. 42 - Describe the advantages and disadvantages of...Ch. 42 - Compare the structures of the egg and sperm. What...Ch. 42 - Prob. 3RQCh. 42 - List the structures, in order, through which a...Ch. 42 - Name the three accessory glands of the male...Ch. 42 - Prob. 6RQCh. 42 - Prob. 1AC
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- Although it is well known that X-rays cause mutations, they are routinely used to diagnose medical problems, including potential tumors, broken bones, and dental cavities. Why is this done? What precautions need to be taken?arrow_forwardI believe that there are many good things that can come out of people getting to design their baby’s genetic material. But there are also many bad things as well. From the article by Bio medical about the pros and cons of having a designer baby it states that a pro is that this type of engineering can “ might help prevent genetic diseases such as Alzheimer’s, Huntington’s Disease, down syndrome, Spinal Muscular Atrophy, and many others”. I think that it is great that we could get rid of Alzheimer’s due to how destructive it can be to the people that suffer it. But I think the other diseases that it can eliminate is horrible due to them making our world a more unique place such as people with autism, Down syndrome. By doing this it could eliminate the whole population of people with disabilities community and make everyone “normal”. Another bad that I found in the article Ethics of designer babies which states that a major flaw for these babies is “designer baby technologies suggest…arrow_forwardOriginal DNA Sequence: TACAC CTTGG CGACGACT... MRNA Sequence: Amino Acid Sequence: Mutated DNA Sequence #5 TACACCTT G G GACGACT... (Highlight the change) What's the mRNA sequence? What will be the amino acid sequence? Will there likely be effects? What type of mutation is this? 1. Which type of mutation is responsible for new variations of a trait? 2. Which type of mutation does not result in an abnormal amino acid sequence? 3. Which type of mutation stops the translation of an mRNA molecule? NOarrow_forward
- What is the purpose of the Human Genome Project? Why do researchers want to know the details of the human genome?arrow_forwardA gene from the bacteria Bacillus thuringiensis has been inserted into the genome of select corn plants. These plants, known as Bt-corn, are capable of producing a toxin that is harmless to humans and other mammals but toxic for the European corn borer, a common pest of corn. What type of genetic technology does the production of Bt-corn represent? cloning O DNA fingerprinting gene therapy O genetic engineering https://student.masteryconnect.com/%23 V4:2 96arrow_forwardWho should be treated by gene therapy? What criteria are used to determine if a person is a candidate for gene therapy? Should gene therapy be used for cosmetic purposes or to improve athletic performance?arrow_forward
- After sequencing a new genome for the first time, functional protein-coding genes are initially identified by: BLAST searches that look for viral integration in the host genome Bioinformatic searches that reveal consensus sequences in expressed genes Aligning expressed exons sequenced from cDNA using transcriptomics B and C A and B Many regions of non-coding eukaryotic DNA previously thought to be "junk" are now known to contain sequence elements important to regulating gene expression. What approach can be used to identify important non-coding regulatory regions when annotating a newly sequenced genome? comparing cDNA to genomic DNA to validate that the gene is expressed identifying restriction enzyme recognition sequences in the genome phylogenetic footprinting to identify conserved non-coding sequences searching for start/stop codons and splice recognition sites that predict where a gene might be located…arrow_forwardBeing able to understand the relationship between DNA, mRNA, tRNA, ribosomes and proteins, is necessary for any researcher interested in gene therapy. Gene therapy is dedicated to correcting genetic defects by replacing mutated genes with wildtype versions. This can include complete removal and introduction of a working copy of the entire gene (using knock-outs and knock-ins) or removal of only the actual mutated nucleotide. Sickle Cell Disease is an example of a recessive disorder based on a single-point mutation: GAG becomes GTG, which encodes a new amino acid. One would only need to replace a single base to correct the disorder making it very attractive to gene therapy researchers. The mutant sickle cell allele is called HbS (for sickled hemoglobin) while the wt allele is HbA. Pretend that Arcel Kasongo, a masters student from Cambridge, is studying for an oral exam on gene therapy, and has an especial interest in the disorder since he comes from the Democratic Republic of Congo…arrow_forwardBeing able to understand the relationship between DNA, mRNA, tRNA, ribosomes and proteins, is necessary for any researcher interested in gene therapy. Gene therapy is dedicated to correcting genetic defects by replacing mutated genes with wildtype versions. This can include complete removal and introduction of a working copy of the entire gene (using knock-outs and knock-ins) or removal of only the actual mutated nucleotide. Sickle Cell Disease is an example of a recessive disorder based on a single-point mutation: GAG becomes GTG, which encodes a new amino acid. One would only need to replace a single base to correct the disorder making it very attractive to gene therapy researchers. The mutant sickle cell allele is called HbS (for sickled hemoglobin) while the wt allele is HbA. Pretend that Arcel Kasongo, a masters student from Cambridge, is studying for an oral exam on gene therapy, and has an especial interest in the disorder since he comes from the Democratic Republic of Congo…arrow_forward
- Do all of them True/False 31) The process by which an electrical charge is used to introduce DNA into a cell to produce a transgenic organism is called electroporation.Answer: 32) Reproductive cloning is used to produce large amounts of mammalian proteins from transgenic agricultural animals such as cattle.Answer: 33) In gene addition, homologous recombination is used to remove the original gene and replace it with the cloned gene.Answer: 34) All stem cells have the potential to differentiateAnswer: 35) A bone marrow transplant involves the transfer of multipotent stem cellsAnswer: 36) The fact that in mammalian systems multiple genes may compensate for the loss of a gene is called gene redundancy.Answer:arrow_forwardDNA technology has many medical applications. Which of the following is not done routinely at present? (A) production of hormones for treating diabetes and dwarfism (B) analysis of gene expression for more informed cancer treatments (C) gene editing by the CRISPR-Cas9 system in viable human embryos to correct genetic diseases (D) prenatal identification of genetic disease allelesarrow_forwardIn the 1996 movie Multiplicity, Doug (Michael Keaton) is a construction worker who wants to spend more time with his family. He meets a friendly scientist (aren't we all?) who has a method for cloning humans. Doug decides to make a clone of himself who can do his work while he spends time with his family. The clone, named "Two", seems great at first, but later develops some functional problems. Two gets tired of working and clones himself to make "Three" to take over. Three then leads to "Four". Each successive clone seems to have an increasing number of issues in function. Ignoring ethical and technical considerations with making adult clones of a human, is there any logical or genetic validity to the premise that make a clone might create problems? If so, what might some of those problems be?arrow_forward
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