Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 3.3, Problem 4TQ
Summary Introduction
To review:
The reason behind the presence of proteins at specific locations in the cell and also mention their inability to function everywhere within the cell.
Introduction:
Amino acids are the organic molecules composed of the side chain, carboxyl group, and an
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The tertiary structure of a protein is the 3-dimensional folding of the polypeptide chain. What types of bonds support the folding of proteins into this level of protein structure? Also, how do these bonds/interactions impact how a protein folds and its surface properties?
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Microbiology: An Evolving Science (Fourth Edition)
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- Which of the following is/are incorrect about the differences between globular and membrane proteins? 1. Membrane proteins are embedded in a lipid environment while globular proteins are solvated by water. 2. The surface of membrane proteins are likely to feature amino acid residues with hydrophobic side chains. 3. Globular proteins, because of their environment, do not have amino acid residues with hydrophobic side chains. 4. No membrane protein has any portions that are exposed to water. O 2 and 3 O 1 O 3 O 4 O 3 and 4arrow_forwardFigure 3.23 Which categories of amino acid would you expect to find on the surface of a soluble protein, and which would you expect to find in the interior? What distribution of amino acids would you expect to find in a protein embedded in a lipid bilayer?arrow_forwardwhat are three proteins that are abundantly present in ECM( Extracellular matrix)?arrow_forward
- a) (i) Give THREE (3) amino acids that most likely can be located in the part of the trans- membrane protein that lies within the cell membrane. Explain why. (ii)Give THREE (3) amino acids that most likely can be located in the part of the transmembrane protein that lies outside the cell membrane. Explain why.arrow_forwardWhy should the BRCA1 protein be considered one of the best macromolecules within proteins? Is BRCA1 the best functionally, structurally, or based on other properties? Please explain in detail. You can give examples with scientific articles related to protein.arrow_forwardGlycophorin is an integral membrane protein found on the surface of red blood cells that is important for binding to the malaria parasite. Name three different amino acids that you might expect to be present in the region of this protein that spans the lipid bilayer and name three different amino acids that you would expect to be absent from this region. For each group, describe what those amino acids have in common that distinguishes them from the other group.arrow_forward
- In the figure below, protein 1 is located in the cytosol, and protein 2 is membrane bound. Give 3 specific examples from Figure 4-3 of amino acids that you might expect to find on the surface of protein 1. For protein 2, give three specific amino acids that you would expect to be on the surface near both points A and B (labeled with stars). To clarify, you should choose 3 amino acids for point A and also list three amino acids for point B. All of the amino acids you choose for Protein 2 must be different from those that you choose for Protein 1. Rationalize your choices by discussing the amino acids you chose, and their properties in a few sentences. Protein 1 Protein 2arrow_forward* hat do you think holds together the various secondary structural elements in a Particular three-dimensional pattern? (Hint: Look back at Figure 4 - what is sticking out from the sides of the a-helices and B-strands?) glutamic acid B CH, CH valine CH H-N CH H. valine alanine CH2 CH2 lysine Figure 4-4 Essential Cell Biology 3/e (O Garland Science 2010) Figure 6. Three examples of bonding interactions that stabilize the tertiary structures of proteins (indicated by arrows A, B,and C). Copyright 2013 from Essential Cell Biology, 4th Edition by Alberts et al. Reproduced by permission Garland Science/ Taylor & Francis LLC. CH2 CH, SH SH CH2 CH2 OXIDATION CH2 SH REDUCTION SH CH2 CH2 Figure 4-26 Essential Cell Bialogy 3e o Garland Science 2010) Figure 7. Disulfide bonds within proteins can form (left-pointing arrow) or be broken (right- pointing arrow), depending on their chemical surroundings (oxidative or reducing). Copyright 2013 from Essential Cell Biology,4th Edition by Alberts et al.…arrow_forwardCan the tertiary structure of a protein depend on the type of cell system used for synthesis? Explain.arrow_forward
- Which categories of amino acid would you expect to find on the surface of a soluble protein, and which would you expect to find in the interior? What distribution of amino acids would you expect to find in a protein embedded in a lipid bilayerarrow_forwardWhat types of amino acids are the least likely to be found in the center of a transmembrane protein? Why?arrow_forwardHow does the process of protein synthesis differ in Prokaryotes and Eukaryotes? Discuss factors other than ribosome size.arrow_forward
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