Loose Leaf For Integrated Principles Of Zoology
18th Edition
ISBN: 9781260411140
Author: Cleveland P Hickman Jr. Emeritus, Susan L. Keen, David J Eisenhour Professor PhD, Allan Larson, Helen I'Anson Associate Professor of Biology
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 30, Problem 13RQ
Explain how the cycling of sodium chloride between the descending and ascending limbs of the loop of Henle in the mammalian kidney, and special permeability of these tubules, produces high osmotic concentrations in interstitial fluids in the kidney medulla. Explain the role of urea in producing high osmotic concentrations in the interstitial fluid of the medulla.
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Explain how the cycling of sodium chloride between the descending and ascending limbs of the loop of Henle in the mammalian kidney, and special permeability of these tubules, produces high osmotic concentrations in interstitial fluids in the kidney medulla. Explain the role of urea in producing high osmotic concentrations in the intersti-tial fluid of the medulla.
The mammalian kidney contains an immense network of nephrons that functions to conserve water by producing urine that is hyperosmotic compared to other body fluids.
Explain how the transport epithelia of the nephron and collecting duct are able to use transport mechanisms to process the filtrate as it moves through the vessels and produce a hyperosmotic filtrate.
The mammalian kidney contains an immense network of nephrons that functions to conserve water by producing urine that is hyperosmotic compared to other body fluids.
Describe in detail how the transport epithelia of the nephron and collecting duct are able to use transport mechanisms to process the filtrate as it moves through the vessels and produce a hyperosmotic filtrate.
Chapter 30 Solutions
Loose Leaf For Integrated Principles Of Zoology
Ch. 30 - Define homeostasis. What evolutionary advantages...Ch. 30 - Describe the physiological challenges confronting...Ch. 30 - Distinguish the terms in the following pairs:...Ch. 30 - Young downstream salmon migrants moving from their...Ch. 30 - Most marine invertebrates are osmotic conformers....Ch. 30 - Prob. 6RQCh. 30 - In what animals would you expect to find a salt...Ch. 30 - Prob. 8RQCh. 30 - Prob. 9RQCh. 30 - Prob. 10RQ
Ch. 30 - In what ways does the nephridium of an earthworm...Ch. 30 - Prob. 12RQCh. 30 - Explain how the cycling of sodium chloride between...Ch. 30 - Explain bow antidiuretic hormone (vasopressin)...Ch. 30 - Prob. 15RQCh. 30 - Large mammals live successfully in deserts and in...Ch. 30 - Prob. 17RQCh. 30 - Prob. 1FFT
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- The Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached) a) Consider the Na+-glucose coupling ratios for SGLT2 and SGLT1. Why would localization of SGLT2 in the early proximal tubule and SGLT1 in the late proximal tubule be advantageous? b) The Michaelis constant (Km) for the SGLT2 and SGLT1 transporters are 2 mM and 0.5 mM, respectively. Is SGLT2 or SGLT1 the higher affinity Na+-glucose transporter? d) Dapagliflozin is an SGLT1 inhibitor and commonly prescribed to treat type 2 diabetes. Why would this be of benefit to a diabetes patient?arrow_forwardthe process that initiates urine formation in most types of vertebrates is ultrafiltration of fluid from the blood plasma into kidney tubules under the force of blood pressure. What properties of the blood plasma in the urine-forming structures of the kidney are likely to affect the rate of ultrafiltration into the kidney tubules? Why is failure of urine production a potential side effect of heart disease?arrow_forwardDescribe the characteristics of the two limbs of the loop of Henle with regard to their transport of Na1, Cl2, and water.arrow_forward
- Renin is secreted in response to hypovolemia or to an increase in the osmolality of the blood. Provide three possible mechanisms by which these conditions may stimulate rennin secretion. What are the consequences of increased rennin secretion that lead to increased aldosterone secretion? Present this sequence of events. Why are angiotensin converting enzyme inhibitors (ACEIs) used as a common therapy for hypertension? How do they influence blood pressure? Are plasma levels of renin elevated or depressed in a patient with Conn’s disease? Why?arrow_forwardThe renal handling of a novel drug is being studied. When the drug is present in the blood, it is filtered into the Bowman’s capsule and secreted via transport proteins in the renal tubules, but it is NOT reabsorbed. The lines on the following graph represent filtration, secretion and excretion rates of this drug at various plasma concentrations. For the three lines shown (labeled A-C) identify which line represents filtration, which line represents secretion, and which line represents excretion Explain how you determined this.arrow_forwardEpithelial cells that reabsorb solutes are cuboidal, but epithelial cells involved in filtration are thin, squamous cells. The cuboidal cells contain more cytoplasm and organelles, especially mitochondria and rough endoplasmic reticulum (RER), than the squamous cells. Why do the cuboidal cells of the kidney tubules need more mitochondria and RER?arrow_forward
- Sodium ion reabsorption from the filtrate into peritubular blood across the cells of this component of the nephron (marked by the black asterisk) Choose from the following: (A) is regulated by the binding of the hormone aldosterone (B) is not regulated by any hormone, but is determined by sodium ion concentration and filtrate flowarrow_forwardExplain how antidiuretic hormone (vasopressin) controls excretion of water in mammalian kidneys.arrow_forwardOne type of diuretic given to people with high blood pressure, renal disease and congestive heart failure are thiazide-type diuretics. These drugs inhibit sodium ion reabsorption by inhibiting the transport in the ascending limb of the loop of Henle. A) What does it mean to inhibit the transport of sodium ions in the loop of Henle? B) Explain how this inhibition of sodium ions in the loop of Henle could help increase urine production.arrow_forward
- Explain how the capacity (function) of the sodium potassium pumps found in the ascending loop of Henle enable the establishment of the medullary concentration gradient.arrow_forwardMannitol is a sugar that does not pass through the walls of capillaries in the brain. It also does not cross the wall of kidney tubules, the structures that transport blood filtrate to become urine. Explain why mannitol can be considered as osmotically active. How might its clinical administration help to prevent swelling of the brain in head trauma? Also, explain the effect it might have on the water content of urine.arrow_forwardA 28-year-old man has a fasting serum glucose concentration of 140 mg/dL and a glomerular filtration rate of 125 ml/min. The renal transport maximum for glucose in this patient is 300 mg/min. Which of the following best represents the rate of urinary glucose excretion (in mg/min) in this man? (A) 0 (B) 100 (C) 200 (D) 300 (E) 400arrow_forward
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