Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 3, Problem 98P
The ε4 allele of the gene encoding apolipoprotein E (APOE) is strongly associated with Alzheimer’s disease, but its value in making the diagnosis remains uncertain. A study was conducted among 2188 patients who were evaluated at autopsy for Alzheimer’s disease by previously established pathological criteria [16]. Patients were also evaluated clinically for the presence of Alzheimer’s disease. The data in Table 3.15 were presented.
Suppose the pathological diagnosis is considered the gold standard for Alzheimer’s disease.
Table 3.15 Relationship between clinical and pathological diagnoses of Alzheimer’s disease
What is the specificity of the test?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Anemia (low healthy blood cells or hemoglobin) has an important role in exercise performance.
However, the direct link between rapid changes of hemoglobin and exercise performance is
still unknown. A study investigated 18 patients with a blood disorder (beta-thalassemia).
Participants in the study performed an exercise test before and the day after receiving a blood
transfusion. Data are given in the table.
HB = Hemoglobin
RER = Respiratory exchange
ID
Change in
HB
Obese
RER > 1.1
ratio
No
No
1
-1.4
No
-1.5
No
Yes
No
Yes
3
-2
No
4
-2.1
No
-1.9
Yes
Yes
No
-1.6
-1.8
-0.8
6
7
No
Yes
No
Yes
8
9.
-1
No
No
-1.2
No
Yes
10
11
No
No
-0.8
-1.5
12
Yes
No
No
Yes
13
14
-1.4
-2.6
-1.7
No
No
Yes
Yes
15
Yes
No
Yes
Yes
16
-2.6
No
17
18
-2.7
-1.5
No
One variety of corn is genetically modified to produce chemicals for defense against predators. The standard corn contains the same standard genotype, but without genetic modification for the chemicals. The two types of corn are then planted in randomly placed adjacent plots across a single field. The amount of predators that are present when the corn has matured are then recorded. The data that was recorded of the predators present among each type are listed.
Has genetic alterations decreased the amount of predators for the altered genotype? Normality tests for the populations of both contain a p value less than 0.05. The given alpha is 0.05
Modified Corn (20, 18, 26, 23, 17, 23, 22)
Standard Corn (89, 64, 102, 96, 56, 77, 84, 59)
use an F test to determine if the variance between the 2 lists are different. Based on this result, state the correct 2 sample parametric test to be used. State the null and alternative. Show calculations while rounding to two decimal points.What is the…
A recent study investigated the association between sudden cardiac death and smoking history in women from a large health system. The epidemiologist reviewed the
electronic health records of women who died from sudden cardiac death (n=80) and women who died of non-cardiac causes (n=80). The investigator then reviewed
these records for smoking history (smoking 1+ pack/day and smoking <1 pack/day) and identified the following results.
Sudden Cardiac Death
38
42
Smoke 1+ pack/day
Smoke <1 pack/day
Calculate the most appropriate measure of association for these data (a)-round to the nearest tenth.
Other Causes
10
70
Chapter 3 Solutions
Fundamentals of Biostatistics
Ch. 3.6 - What is the frequency definition of probability?Ch. 3.6 - What is the difference between independent and...Ch. 3.6 - What are mutually exclusive events?Ch. 3.6 - What is the addition law of probability?Ch. 3.6 - What is conditional probability? How does it...Ch. 3.6 - What is relative risk? How do you interpret it?Ch. 3.6 - Prob. B.1RECh. 3.6 - Suppose the rate of type II diabetes mellitus (DM)...Ch. 3.7 - What is the sensitivity and specificity of a...Ch. 3.7 - What are the PV+ and PV of a screening test? How...
Ch. 3.7 - Prob. C.3RECh. 3.7 - What is Bayes rule? How is it used?Ch. 3.7 - Prob. D.2RECh. 3.7 - Prob. D.3RECh. 3.7 - Prob. D.4RECh. 3.10 - Suppose that of 25 students in a class, 5 are...Ch. 3.10 - Suppose 50 HIV-positive men are identified, 5 of...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Prob. 11PCh. 3 - Suppose an influenza epidemic strikes a city. In...Ch. 3 - Suppose there is a 20% chance each child will get...Ch. 3 - Suppose there is a 20% chance each child will get...Ch. 3 - Suppose there is a 20% chance each child will get...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Suppose a study of Alzheimers disease is proposed...Ch. 3 - Suppose a study of Alzheimers disease is proposed...Ch. 3 - Commonly used vaccines for influenza are trivalent...Ch. 3 - Prob. 29PCh. 3 - Prob. 30PCh. 3 - Prob. 31PCh. 3 - Genetics Suppose that a disease is inherited via a...Ch. 3 - Genetics Suppose that a disease is inherited via a...Ch. 3 - Genetics Suppose that a disease is inherited via a...Ch. 3 - Prob. 35PCh. 3 - Prob. 36PCh. 3 - Suppose that a disease is inherited via an...Ch. 3 - Suppose that a disease is inherited via an...Ch. 3 - Prob. 39PCh. 3 - Suppose that a disease is inherited via a...Ch. 3 - Suppose that a disease is inherited via a...Ch. 3 - Suppose that a disease is inherited via a...Ch. 3 - Suppose that a disease is inherited via a...Ch. 3 - Prob. 44PCh. 3 - Prob. 45PCh. 3 - Prob. 46PCh. 3 - Prob. 47PCh. 3 - Prob. 48PCh. 3 - Prob. 49PCh. 3 - Obstetrics The following data are derived from the...Ch. 3 - Obstetrics The following data are derived from the...Ch. 3 - Obstetrics The following data are derived from the...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Suppose, alternatively, that if the father is a...Ch. 3 - Suppose, alternatively, that if the father is a...Ch. 3 - Prob. 57PCh. 3 - The familial aggregation of respiratory disease is...Ch. 3 - The familial aggregation of respiratory disease is...Ch. 3 - The familial aggregation of respiratory disease is...Ch. 3 - The familial aggregation of respiratory disease is...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Genetics, Obstetrics Precise quantification of...Ch. 3 - Precise quantification of smoking during pregnancy...Ch. 3 - Precise quantification of smoking during pregnancy...Ch. 3 - What is another name for this quantity? Suppose it...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Pulmonary Disease Research into cigarette-smoking...Ch. 3 - Pulmonary Disease Research into cigarette-smoking...Ch. 3 - Laboratory measures of cardiovascular reactivity...Ch. 3 - Laboratory measures of cardiovascular reactivity...Ch. 3 - Laboratory measures of cardiovascular reactivity...Ch. 3 - The data set in Table 3.12 is based on 214...Ch. 3 - The data set in Table 3.12 is based on 214...Ch. 3 - The data set in Table 3.12 is based on 214...Ch. 3 - A drug company is developing a new pregnancy-test...Ch. 3 - A drug company is developing a new pregnancy-test...Ch. 3 - A drug company is developing a new pregnancy-test...Ch. 3 - Gynecology A drug company is developing a new...Ch. 3 - The Chinese Mini-Mental Status Test (CMMS)...Ch. 3 - The Chinese Mini-Mental Status Test (CMMS)...Ch. 3 - Mental Health The Chinese Mini-Mental Status Test...Ch. 3 - Construct an ROC curve based on the table...Ch. 3 - Mental Health The Chinese Mini-Mental Status Test...Ch. 3 - Calculate the area under the ROC curve. Interpret...Ch. 3 - Demography A study based on data collected from...Ch. 3 - Prob. 94PCh. 3 - Demography A study based on data collected from...Ch. 3 - Demography A study based on data collected from...Ch. 3 - Prob. 97PCh. 3 - The 4 allele of the gene encoding apolipoprotein E...Ch. 3 - Mental Health The 4 allele of the gene encoding...Ch. 3 - Mental Health The 4 allele of the gene encoding...Ch. 3 - Cardiovascular Disease A fascinating subject of...Ch. 3 - Cardiovascular Disease A fascinating subject of...Ch. 3 - Are these proportions prevalence rates, incidence...Ch. 3 - Prob. 104PCh. 3 - A dominantly inherited genetic disease is...Ch. 3 - A dominantly inherited genetic disease is...Ch. 3 - Prob. 107PCh. 3 - Infectious Disease, Cardiovascular Disease A...Ch. 3 - Infectious Disease, Cardiovascular Disease A...Ch. 3 - Infectious Disease, Cardiovascular Disease A...Ch. 3 - Prob. 114PCh. 3 - Genetics Suppose a birth defect has a recessive...Ch. 3 - A further study finds that after 10 generations...Ch. 3 - A further study finds that after 10 generations...Ch. 3 - Orthopedics Piriformis syndrome is a pelvic...Ch. 3 - Prob. 119PCh. 3 - Orthopedics Piriformis syndrome is a pelvic...Ch. 3 - Prob. 121PCh. 3 - Cancer Breast cancer is considered largely a...Ch. 3 - Cancer Breast cancer is considered largely a...Ch. 3 - Cancer Breast cancer is considered largely a...Ch. 3 - Prob. 125PCh. 3 - Cardiovascular Disease Mayo Clinic investigators...Ch. 3 - Prob. 127PCh. 3 - Prob. 128PCh. 3 - Prob. 129PCh. 3 - Prob. 130PCh. 3 - Prob. 131PCh. 3 - Prob. 132PCh. 3 - Radiology Mobile displays have the potential to...Ch. 3 - Radiology Mobile displays have the potential to...Ch. 3 - Prob. 135PCh. 3 - Prob. 136PCh. 3 - Prob. 137PCh. 3 - Cardiovascular Disease The ankle-arm...Ch. 3 - Cardiovascular Disease The ankle-arm...Ch. 3 - Cardiovascular Disease The ankle-arm...Ch. 3 - Prob. 141PCh. 3 - Prob. 142PCh. 3 - Prob. 143PCh. 3 - Obstetrics, Health Promotion A study was performed...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, statistics and related others by exploring similar questions and additional content below.Similar questions
- A clinical trial of gamma globulin in the treatment of children with Kawasaki syndrome randomized approximately half of the patients to receive gamma globulin. The standard treatment is an aspirin regimen; however, about one quarter of these patients developed coronary abnormalities even, under the standard treatment. The outcome of interest was the development of coronary abnormalities (CA) over a 7-week follow-up period. The following 2 x 2 table summarizes the results. a) Calculate the odds of developing coronary abnormalities for those who took gamma globulin. Calculate the odds of developing coronary abnormalities for those who took aspirin. (b) Calculate the sample OR for developing coronary abnormalities comparing those on gamma globulin compared to those on aspirin. (c) Investigators constructed the following logistic model: where Logit(i) = log [i / (1 - i) ] = = – 1.0076 – 1.4030 GG Does it make sense to interpret the intercept in this model? If…arrow_forwardIn a study of 301 Hispanic women living in San Antonia, Texas, one variable of interest was the percentage of subjects with impaired fasting glucose (IFG). IFG refers to a metabolic stage intermediate between normal glucose homeostasis and diabetes. In the study, 24 women were classified in the IFG stage. The article cites population estimates for IFG among Hispanic women in Texas as 6.3%. Is there sufficient evidence to indicate the population of Hispanic women in San Antonio has a prevalence of IFG higher than 6.3%? Use 95% confidence level and the p -value method to form your conclusion. The computed z score was 1.193. Find the p-value.arrow_forwardIn a study of 301 Hispanic women living in San Antonia, Texas, one variable of interest was the percentage of subjects with impaired fasting glucose (IFG). IFG refers to a metabolic stage intermediate between normal glucose homeostasis and diabetes. In the study, 24 women were classified in the IFG stage. The article cites population estimates for IFG among Hispanic women in Texas as 6.3%. Is there sufficient evidence to indicate the population of Hispanic women in San Antonio has a prevalence of IFG higher than 6.3%? Use 95% confidence level and the p -value method to form your conclusion. Choose the correct null and alternative hypothesis.arrow_forward
- A data set from a study that examined the effect of a specific diet on blood pressure is provided . Participants (n = 72) were randomly assigned either to a group that was put on the diet (Diet = Present) or to a group that was not put on the diet (Diet = Absent), and researchers wanted to know whether the diet had a significant impact on blood pressure. Fully interpret the results in the context of this study (i.e., report the conclusions as related to the research question).arrow_forwardResearchers have noted a decline in cognitive functioning as people age (Bartus, 1990). However, the results from other research suggest that the antioxidants in foods such as blueberries may reduce and even reverse these age-related declines (Joseph et al., 1999). To examine this phenomenon, suppose that a researcher obtains a sample of n = 16 adults who are between the ages of 65 and 75. The researcher uses a standardized test to measure cognitive performance for each individual. The participants then begin a 2-month program in which they receive daily doses of a blueberry supplement. At the end of the 2-month period, the researcher again measures cognitive performance for each participant. The results show an average increase in performance of MD = 7.4 with SS = 1215. Does this result support the conclusion that the antioxidant supplement has a significant effect on cognitive performance? Use a two-tailed test with α = .05. Show your computations.arrow_forwardResearchers have noted a decline in cognitive functioning as people age (Bartus, 1990). However, the results from other research suggest that the antioxidants in foods such as blueberries may reduce and even reverse these age-related declines (Joseph et al., 1999). To examine this phenomenon, suppose that a researcher obtains a sample of n = 16 adults who are between the ages of 65 and 75. The researcher uses a standardized test to measure cognitive performance for each individual. The participants then begin a 2-month program in which they receive daily doses of a blueberry supplement. At the end of the 2-month period, the researcher again measures cognitive performance for each participant. The results show an average increase in performance of Mp = 7.4 with SS = 1215. a. Does this result support the conclusion that the antioxidant supplement has a significant effect on cognitive performance? Use a two-tailed test with a = = .05. (1) Ho: (Select] ( Select ] [ Select ] H: ( Select ] […arrow_forward
- Although arsenic is known to be a poison, it also has some beneficial medicinal uses. In one study of the use of arsenic to treat acute promyelocytic leukemia (APL), a rare type if blood cancer, APL patients were given an arsenic compound as part of their treatment. Of those receiving arsenic, 32% were in remission and showed no signs of leukemia in subsequent examination. It is known that 18% of APL patients go into remission after conventional treatment. Suppose that the study had included 100 randomly selected patients. Is there sufficient evidence to conclude that the proportion in remission for the arsenic treatment is greater than 0.18, the remission proportion for conventional treatment? a. Test the hypothesis at the 0.01 significance level. b. Construct and interpret a 99% confidence interval for the true proportion of APL patients who go into remission after using arsenic. Does the inference drawn from this interval match the conclusion from the test that you did in part…arrow_forwardThe Joint Commission on Accreditation of Healthcare Organizations mandated that hospitals ban smoking by 1994. To study the effects of this ban on smoking behaviors, subjects were randomly selected from two different populations: those from hospitals with the ban and those from hospitals without the ban. Investigators were interested in determining if this smoking ban had any impact on the proportion of smokers employed at each hospital that then quit smoking. Let px be the proportion of smokers from hospitals that implemented the ban who quit smoking during the study period. Let py be the proportions of smokers from hospitals without the ban who quit smoking during the study period. Please select the appropriate hypotheses. H0: px = 0.50 HA: px ≠ 0.50 H0: px-py ≥ 0 HA: px-py H0: px-py ≤ 0 HA: px-py > 0 H0: px-py = 0 HA: px-py ≠ 0arrow_forward
arrow_back_ios
arrow_forward_ios
Recommended textbooks for you
Holt Mcdougal Larson Pre-algebra: Student Edition...AlgebraISBN:9780547587776Author:HOLT MCDOUGALPublisher:HOLT MCDOUGAL
Calculus For The Life SciencesCalculusISBN:9780321964038Author:GREENWELL, Raymond N., RITCHEY, Nathan P., Lial, Margaret L.Publisher:Pearson Addison Wesley,
Big Ideas Math A Bridge To Success Algebra 1: Stu...AlgebraISBN:9781680331141Author:HOUGHTON MIFFLIN HARCOURTPublisher:Houghton Mifflin Harcourt
Glencoe Algebra 1, Student Edition, 9780079039897...AlgebraISBN:9780079039897Author:CarterPublisher:McGraw Hill
Holt Mcdougal Larson Pre-algebra: Student Edition...
Algebra
ISBN:9780547587776
Author:HOLT MCDOUGAL
Publisher:HOLT MCDOUGAL
Calculus For The Life Sciences
Calculus
ISBN:9780321964038
Author:GREENWELL, Raymond N., RITCHEY, Nathan P., Lial, Margaret L.
Publisher:Pearson Addison Wesley,
Big Ideas Math A Bridge To Success Algebra 1: Stu...
Algebra
ISBN:9781680331141
Author:HOUGHTON MIFFLIN HARCOURT
Publisher:Houghton Mifflin Harcourt
Glencoe Algebra 1, Student Edition, 9780079039897...
Algebra
ISBN:9780079039897
Author:Carter
Publisher:McGraw Hill
Hypothesis Testing - Solving Problems With Proportions; Author: The Organic Chemistry Tutor;https://www.youtube.com/watch?v=76VruarGn2Q;License: Standard YouTube License, CC-BY
Hypothesis Testing and Confidence Intervals (FRM Part 1 – Book 2 – Chapter 5); Author: Analystprep;https://www.youtube.com/watch?v=vth3yZIUlGQ;License: Standard YouTube License, CC-BY