Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 28, Problem 2P
Interpretation Introduction
Interpretation:
Among the given compounds, the compound which satisfies all of Lipinski’s rules should be identified.
Concept introduction:
Lipinski’s rule also known as Pfizer’s rule of five. It is a thumb rule to determine that a chemical compound with biological or pharmacological activity will likely be an orally active drug or not.
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a. The penultimate carbon in an aldohexose is C-5 which is the last chiral carbon in the structure counting from the aldehydic carbon or C-1.
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