Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Question
Chapter 28, Problem 11P
Interpretation Introduction
Interpretation:
The reason for the effectiveness of Gleevec or imatinib mesylate in cancer chemotherapy should be determined.
Concept introduction:
Chemotherapy is a type of therapy in which a drug is used to cure any disease. Chemotherapy is a type of radiation therapy and surgery that is used to remove, kill, or damage cancer cells in some body part, but chemo can work all over the body.
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True or False. Explain.
A) At no time during protein synthesis does an amino acid make direct
contact with the mRNA being translated.
B) Because the two strands of DNA are complementary, the mRNA of a gene can be synthesized using either strand as a template.
. CTP synthetase catalyzes the glutamine-dependent conversion of
UTP to CTP. The enzyme is allosterically inhibited by the product,
CTP. Mammalian cells defective in this allosteric inhibition are
found to have a complex phenotype: They require thymidine in the
growth medium, they have unbalanced nucleotide pools, and they
have a mutator phenotype. Explain the basis for these observations.
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