Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 27, Problem 40P
Interpretation Introduction
Interpretation:
The reason for mitochondrial biogenesis should be determined due to prolonged exercises.
Concept introduction:
The production of new organelles or living organisms is termed as biogenesis. Biogenesis is based on the Louis Pasteur theory that, living organisms come from another living thing only, that is, through reproduction. Mitochondrial biogenesis refers to the production of more mitochondria from the preexisting mitochondria.
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Fo-F1 ATPase. The energy for ATP synthesis from ADP and Pi is provided by the downhill transport of protons through the rotary FoF1 ATP synthase . The enzyme has 3 alpha-beta and 12 ‘c’ subunits. The mitochondrion maintains change in membrane potential=180 mV (negative inside), pHin = 8, pHout=7, [Pi] = 3 mM and ADP is present as well.
. What [ATP]/[ADP] ratio will be established at steady-state under these conditions?
What would be the [ATP]/[ADP] ratio if the enzyme had only 9 ‘c’ subunits? full revolution of the crank (gamma subunit) produces 3 ATP.
Fo-F1 ATPase. The energy for ATP synthesis from ADP and Pi is provided by the downhill transport of protons through the rotary FoF1 ATP synthase (lecture 22). The enzyme has 3 a-b and 12 ‘c’ subunits. The mitochondrion maintains Df=180 mV (negative inside), pHin = 8, pHout=7, [Pi] = 3 mM and ADP is present as well.
How much energy is available (from the proton electrochemical gradient) for ATP synthesis under these conditions (in kJ/mol)?
What [ATP]/[ADP] ratio will be established at steady-state under these conditions?
What would be the [ATP]/[ADP] ratio if the enzyme had only 9 ‘c’ subunits? Remember that full revolution of the crank (gamma subunit) produces 3 ATP.
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Chapter 27 Solutions
Biochemistry
Ch. 27 - Prob. 1PCh. 27 - Prob. 2PCh. 27 - Prob. 3PCh. 27 - Prob. 4PCh. 27 - Prob. 5PCh. 27 - Prob. 6PCh. 27 - Prob. 7PCh. 27 - Prob. 8PCh. 27 - Prob. 9PCh. 27 - Prob. 10P
Ch. 27 - Prob. 11PCh. 27 - Prob. 12PCh. 27 - Prob. 13PCh. 27 - Prob. 14PCh. 27 - Prob. 15PCh. 27 - Prob. 16PCh. 27 - Prob. 17PCh. 27 - Prob. 18PCh. 27 - Prob. 19PCh. 27 - Prob. 20PCh. 27 - Prob. 21PCh. 27 - Prob. 22PCh. 27 - Prob. 23PCh. 27 - Prob. 24PCh. 27 - Prob. 25PCh. 27 - Prob. 26PCh. 27 - Prob. 27PCh. 27 - Prob. 28PCh. 27 - Prob. 29PCh. 27 - Prob. 30PCh. 27 - Prob. 31PCh. 27 - Prob. 32PCh. 27 - Prob. 33PCh. 27 - Prob. 34PCh. 27 - Prob. 35PCh. 27 - Prob. 36PCh. 27 - Prob. 37PCh. 27 - Prob. 38PCh. 27 - Prob. 39PCh. 27 - Prob. 40PCh. 27 - Prob. 41PCh. 27 - Prob. 42PCh. 27 - Prob. 43PCh. 27 - Prob. 44PCh. 27 - Prob. 45PCh. 27 - Prob. 46PCh. 27 - Prob. 47PCh. 27 - Prob. 48PCh. 27 - Prob. 49PCh. 27 - Prob. 50PCh. 27 - Prob. 51PCh. 27 - Prob. 52PCh. 27 - Prob. 53P
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