Brock Biology of Microorganisms (15th Edition)
15th Edition
ISBN: 9780134261928
Author: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl
Publisher: PEARSON
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Chapter 26.5, Problem 1CR
Pathogens may colonize host tissues when appropriate nutrients and growth conditions are present, such as on mucosal surfaces, especially where the composition of the normal microbiota has been altered. Innate responses to microbial invasion and tissue damage are initiated by the release of chemokines, which recruit phagocytes and other immune cells to sites of infection.
Describe a scenario in which microorganisms invade body tissues. What factors allow for the migration of phagocytes to sites of infection?
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Chapter 26 Solutions
Brock Biology of Microorganisms (15th Edition)
Ch. 26.1 - What major class of immune cells mediates an...Ch. 26.1 - Prob. 2MQCh. 26.1 - Compare and contrast the major features of innate...Ch. 26.2 - Describe host tissue specificity for pathogens.Ch. 26.2 - Identify physical and chemical barriers to...Ch. 26.2 - What other factors may control the outcome of an...Ch. 26.2 - Identify at least four mechanisms by which a...Ch. 26.3 - Describe the circulation of a leukocyte from the...Ch. 26.3 - What soluble molecules determine whether a...Ch. 26.3 - Cells involved in innate and adaptive immunity...
Ch. 26.4 - How does the development of B, T, and NK cells...Ch. 26.4 - Distinguish between the primary lymphoid organs...Ch. 26.4 - Leukocytes are differentiated white blood cells...Ch. 26.5 - Although technically not part of the immune...Ch. 26.5 - Describe the mechanisms by which circulating...Ch. 26.5 - Pathogens may colonize host tissues when...Ch. 26.6 - Identify a PAMP shared by a group of...Ch. 26.6 - Outline the general features of a signal...Ch. 26.6 - Innate recognition of common pathogens occurs...Ch. 26.7 - Identify the mechanism used by phagocytes to...Ch. 26.7 - Describe several reasons why phagocytes are not...Ch. 26.7 - Phagocytosis is the engulfing of infectious...Ch. 26.8 - Prob. 1MQCh. 26.8 - Identify the major symptoms of localized...Ch. 26.8 - Fever and inflammation, characterized by pain,...Ch. 26.9 - In what ways does the classical pathway of...Ch. 26.9 - What is opsonization, and how does opsonization...Ch. 26.9 - Why are the mannose-binding lectin and alternative...Ch. 26.9 - The complement system is composed of soluble...Ch. 26.10 - Prob. 1MQCh. 26.10 - Prob. 2MQCh. 26.10 - Prob. 1CRCh. 26 - Prob. 1AQCh. 26 - Describe the potential problems that would arise...Ch. 26 - Prob. 3AQCh. 26 - Prob. 4AQ
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- Pathogenic organisms cause damage to the host by a variety of mechanisms, depending on the category of the pathogen and its mode of replication in the host. Give an example of two different types of pathogens that are unlikely to be dealt with by the same mechanism of immune protection.arrow_forwardDescribe how phagocytes recognize foreign cells. Explain the mechanism phagocytes use to kill engulfed cells. List some ways pathogens avoid the consequences of phagocytosis. Describe the cause, advantages and disadvantages of fever. Define complement and its role in host defensearrow_forwardWhy is the evasion of phagocytosis a type of virulence factor?arrow_forward
- All of the following are methods intracellular pathogens can use to survive inside a host cell EXCEPT create a capsule. Escape the phagosome. survive in the phagolysosome. prevent phagosome-lysosome fusion.arrow_forwardThe complement system supplements the inflammatory response by directly killing microorganisms. Describe the life cycle of complement proteins, from their synthesis in the liver to their activity in the site of an infection.arrow_forwardThe circulating cytokines that recruit large numbers of phagocytes to the area of inflammation, resulting in pus, are called: O1) pyogens O 2) pyrogens 3) interferons O 4) defensinsarrow_forward
- What is the expected result if a compromised person is exposed to a true pathogen?arrow_forwardDescribe an immunodeficiency that a person could have that would cause the immune system to select the incorrect immune response to Mycobacterium leprae.What gene would be mutated and how would this alter the immune response to this pathogen?arrow_forwardDuring inflammaion, host tissue may be damaged owing to the release of toxic oxygen derivatives produced by activated phagocytes. List some of hese toxic species and explain what cellular/biochemical mechanisms limit these damaging off-target effects.arrow_forward
- An adaptive immune response underlying coeliac disease pathogenesis involves: a) Production of Th1 (T helper cell 1 type) cytokines that act to promote the production of antibodies to gluten peptides b) Production of anti-gliadin and anti-tissue transglutaminase antibodies via TH2 cytokines c) Conversion of glutamate to glutamine by deamination d) The early recognition of gluten peptides via pattern recognition receptors on epithelial cells and the subsequent release of Interleukin 15arrow_forward“Good” bacteria help prevent C. difficile infection by occupying the sites on the intestinal wall where C. difficile could attach and multiply. C. difficile produces toxins that activate macrophages and mast cells, cause leukocyte chemotaxis and the production of chemical mediators, which leads to fluid secretion. What type of response(s) is (are) characterized by these processes? Would this be inflammation? Or would it be a cell-mediated response, specific immune response? Or humoral response with T cells perhaps? I'm having a lot of trouble identifying the biological immune mechanism.arrow_forwardMacrophages and neutrophils both contribute to extracellular pathogen protection. Describe their common characteristics, differences in structure and function, and if one were eliminated from the innate immune response, explain which one would be more detrimental to the body and why.arrow_forward
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