Becker's World of the Cell (9th Edition)
Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 26, Problem 1Q

Monoclonal antibodies directed against the CD20 antigen are used to treat certain forms of lymphoma. However, the CD20 antigen is present on both mature normal and malignant lymphocytes, and treatment with the antibody therefore kills normal cells as well as cancer cells. Why do you think this antibody still turns out to be an effective treatment for lymphoma?

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Please could you explain how lymphocytes (especially B) can maintain receptors on their surfaces? Is this genetically related? If so, when the lymphocytes are first exposed to the antigens, how could the antigen receptor be synthesized? Is there a mutation within the nuclei of these lymphocytes when they learn to make the receptors? If there is, can you explain how this occurs?
How do T cells, NK cells and macrophages recognize and destroy cells? How do cancer cells protect themselves from these cells?   Explain how monoclonal antibodies and CAR-T-cells are used in cancer therapy. What are the advantages of these therapies?
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