Some viruses have mechanisms to down-regulate MHC class I protein expression on the surface of cells in which the virus is replicating. This immune evasion strategy might prevent effector CD8 cytotoxic T cells from recognizing and killing the virus-infected cells. Would this immune evasion strategy also prevent the initial activation of virus-specific CD8 T cells?Yes, because no viral peptide:MHC class I complexes would form to activate CD8 T cells.No, because dendritic cells would take up infected cells and cross-present viral peptides to activate CD8 T cells.No, because some presentation of MHC class I complexes with viral peptides would occur before the virus could down-regulate all the surface MHC class I protein.Yes, because this immune evasion strategy would also function in dendritic cells, even if the virus doesn’t replicate in dendritic cells.No, because the type I interferon response induced by the virus infection will up-regulate MHC class I expression and override the immune evasion mechanism.

To maximize the probability of pathogenic organisms being transmitted to a fresh host a strategy is…

Answered: Some viruses have mechanisms to…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 11QP: It is often helpful to draw a complicated pathway in the form of a flow chart to visualize the...

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Some viruses have mechanisms to down-regulate MHC class I protein expression on the surface of cells in which the virus is replicating. This immune evasion strategy might prevent effector CD8 cytotoxic T cells from recognizing and killing the virus-infected cells. Would this immune evasion strategy also prevent the initial activation of virus-specific CD8 T cells?

Yes, because no viral peptide:MHC class I complexes would form to activate CD8 T cells.
No, because dendritic cells would take up infected cells and cross-present viral peptides to activate CD8 T cells.
No, because some presentation of MHC class I complexes with viral peptides would occur before the virus could down-regulate all the surface MHC class I protein.
Yes, because this immune evasion strategy would also function in dendritic cells, even if the virus doesn’t replicate in dendritic cells.
No, because the type I interferon response induced by the virus infection will up-regulate MHC class I expression and override the immune evasion mechanism.

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