Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 26, Problem 16E
Summary Introduction
To explain: The biological function of linking of 5ʹ end of regulatory RNAs to 3ʹ-OH group of adenosine residue of NAD+ and how the activity of a modified RNA might reflect the cell’s overall
Introduction: Bacterial RNA polymerases initiate transcription with the adenosine residue of NAD+. Bacterial regulatory RNAs are a group of heterogenous molecules such as riboswitches. They act to modulate various physiological responses.
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Geranylgeranyl pyrophosphate 5 is converted by general acid-base catalysis to 6, and then to the natural product 7. For clarity only limited atom numbers are shown, but the main chain carbons are numbered 1 to 16, and the off-chain methyl substituents are numbered 17-20.
A. Based on what you specified in A, use curly arrows on the drawing above to convert 5 to 6, and 6 to 7. Invoke general acids and general bases as needed, and draw in hydrogens as necessary .
B. On the structure of 7, write in the atom numbers for the carbons marked with an asterisk
α-Pinene (4) is synthesized enzymatically from nerol pyrophosphate 1. Drawn an arrow-pushing mechanism from 1 to 2 to 3 to 4; add explicit hydrogens to clarify, if needed.
A reverse phase column chromatography separates proteins according to their polarity. Which pentapeptide will be eluted FIRST when chromatographed at pH 7 using a reverse phase column such as a C-18 column?
Peptide Sequence (from N-terminal to C-terminal)
AKGED
GAAVF
ALLLI
MCYAG
GAAVF
MCYAG
ALLLI
AKGED
Chapter 26 Solutions
Fundamentals of Biochemistry: Life at the Molecular Level
Ch. 26 - Prob. 1ECh. 26 - 2. The bacterial enzyme polynucleotide...Ch. 26 - Prob. 3ECh. 26 - Prob. 4ECh. 26 - Prob. 5ECh. 26 - Prob. 6ECh. 26 - Prob. 7ECh. 26 - Prob. 8ECh. 26 - Prob. 9ECh. 26 - 10. Certain E. coli bacteriophages encode a...
Ch. 26 - Prob. 11ECh. 26 - Prob. 12ECh. 26 - 13. Compare DNA polymerase, RNA polymerase, poly...Ch. 26 - Prob. 14ECh. 26 - Prob. 15ECh. 26 - Prob. 16ECh. 26 - Prob. 17ECh. 26 - Prob. 18ECh. 26 - Prob. 19ECh. 26 - Prob. 20ECh. 26 - Prob. 21ECh. 26 - Prob. 22ECh. 26 - Prob. 23CQCh. 26 - Prob. 24CQCh. 26 - Prob. 25CQCh. 26 - Prob. 26CQCh. 26 - Prob. 27CQCh. 26 - Prob. 28CQCh. 26 - Prob. 29CQCh. 26 - Prob. 30CQCh. 26 - Prob. 1MTE
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