Campbell Essential Biology with Physiology (6th Edition)
Campbell Essential Biology with Physiology (6th Edition)
6th Edition
ISBN: 9780134711751
Author: Eric J. Simon, Jean L. Dickey, Jane B. Reece
Publisher: PEARSON
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Chapter 24, Problem 15PS

Tuberculosis (TB) is caused by a bacterium spread from person to person through the air. It affects the lungs, but can also affect the kidneys, brain, and spine. A simple diagnostic test for TB involves injecting antigen (from the bacterium that causes TB) under the skin and then waiting a few days for a reaction to appear. If a reaction occurs, a person has the TB infection (although the majority of people won’t develop an active disease with symptoms). Would this test be useful in diagnosing TB in patients with AIDS? Predict whether patients with both AIDS and TB infection would have a positive skin test or not.

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If the person has been vaccinated against tetanus, he is given a booster which consists of the toxin. If the patient has never been vaccinated against tetanus, he is given an antiserum shot against tetanus. Explain the rationale for this treatment strategy. Sometimes both booster and antiserum are given at different locations of the body. Explain why this is done.
Before you can start your clinical rotation, you are required to get a tuberculosis (TB) test. The clinician injects a small amount of tuberculin purified protein derivative (PPD) under the skin of your forearm. Within about 30 minutes, you develop a swollen, itchy rash on your forearm where the PPD was injected. What type of hypersensitivity is this? What might have caused this result?
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