Principles of Human Physiology (6th Edition)
6th Edition
ISBN: 9780134169804
Author: Cindy L. Stanfield
Publisher: PEARSON
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Textbook Question
Chapter 23, Problem 10E
Foreign antigens phagocytosed by macrophages are presented by
a. class I MHC molecules to cytotoxic T cells.
b. class II MHC molecules to helper T cells.
c. class I MHC molecules to helper T cells.
d. class II MHC molecules to CD8-bearing cells.
e. class II MHC molecules to cytotoxic T cells.
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Students have asked these similar questions
Which of the following are TRUE of class I major histocompatibility complex (MHC) molecules? a. Class I MHC molecules present endogenous antigens. b. Class I MHC molecules are only present on erythrocyte surfaces. c. Class I MHC molecules bind complement. d. Class I MHC molecules present exogenous antigens.
Which of the following statements are true for antigen presentation.
a.
Antigen presentation means that other cells attach the pathogen first and present it to T cells.
b.
Antigen-presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor to B cells
c.
Antigen presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor on their surface.
d.
Antigen-presenting cells are phagocytic cells
e.
Antigen presentation is required for T cell activation
f.
Cytokines released by macrophages are required for T cell activation
g.
T cell receptors recognize the MHC receptors in complex with antigen fragments displayed by antigen-presenting cells.
h.
Phagocytic cells are involved in innate immunity. Therefore they have no role in T-cell activation
Which of the following explains why dendritic cells, but not macrophages or B cells, contribute to the activation of naive T cells?
a. Macrophages and B cells do not express MHC class II molecules until they are activated.
b. Dendritic cells upregulate B7 after engaging innate immunity receptors at sites of infection.
c. Dendritic cells express higher levels of CTLA4.
d. Macrophages and B cells do not process antigen.
e. Dendritic cells use Toll-like receptors to hold antigen in place for extended periods of time.
Chapter 23 Solutions
Principles of Human Physiology (6th Edition)
Ch. 23.1 - Prob. 23.1.1QCCh. 23.1 - Name the two central lymphoid tissues. Why are...Ch. 23.2 - Prob. 23.2.1QCCh. 23.2 - Prob. 23.2.2QCCh. 23.3 - Prob. 23.3.1QCCh. 23.3 - Prob. 23.3.2QCCh. 23.3 - Prob. 23.3.3QCCh. 23.3 - Prob. 23.3.4QCCh. 23.3 - Prob. 1CTQCh. 23.3 - Prob. 2CTQ
Ch. 23.3 - Prob. 3CTQCh. 23.3 - Prob. 23.4.1QCCh. 23.3 - Prob. 23.4.2QCCh. 23.3 - Prob. 23.4.3QCCh. 23.3 - Prob. 23.4.4QCCh. 23.4 - Prob. 23.5.1QCCh. 23.4 - Prob. 23.5.2QCCh. 23.4 - Prob. 23.5.3QCCh. 23.5 - Prob. 23.6.1QCCh. 23.5 - Prob. 23.6.2QCCh. 23.5 - Prob. 23.6.3QCCh. 23.5 - Prob. 23.6.4QCCh. 23.6 - Prob. 1CTQCh. 23.6 - Prob. 2CTQCh. 23.6 - Prob. 3CTQCh. 23.6 - Prob. 23.7.1QCCh. 23.6 - Prob. 23.7.2QCCh. 23.6 - Prob. 1aCTQCh. 23.6 - Prob. 2aCTQCh. 23.6 - Prob. 3aCTQCh. 23.6 - Which class of antibody is induced in allergies...Ch. 23.6 - Does rheumatoid arthritis result from a humoral...Ch. 23.6 - Name two lymphoid organs that are innervated by...Ch. 23.6 - Prob. 1bCTQCh. 23.6 - Prob. 2bCTQCh. 23.6 - Prob. 3bCTQCh. 23 - Prob. 1ECh. 23 - Prob. 2ECh. 23 - Prob. 3ECh. 23 - Lymphocytes contact foreign antigen in all of the...Ch. 23 - Which of the following is not true about humoral...Ch. 23 - Macrophages
a. are derived from monocytes.
b....Ch. 23 - Activated cytotoxic T cells release pore-forming...Ch. 23 - Prob. 8ECh. 23 - Prob. 9ECh. 23 - Foreign antigens phagocytosed by macrophages are...Ch. 23 - Of the following events, which occurs earliest in...Ch. 23 - Prob. 12ECh. 23 - Prob. 13ECh. 23 - Prob. 14ECh. 23 - Prob. 15ECh. 23 - Fill in the blank with the abbreviation for the...Ch. 23 - Fill in the blank with the letter that applies to...Ch. 23 - A person who experiences life-threatening allergic...Ch. 23 - Prob. 19ECh. 23 - Prob. 20ECh. 23 - Prob. 21ECh. 23 - Prob. 22ECh. 23 - Prob. 23ECh. 23 - Prob. 24ECh. 23 - Prob. 25ECh. 23 - Immune responses exhibit four features, all of...Ch. 23 - Prob. 27ECh. 23 - Prob. 28ECh. 23 - Prob. 29ECh. 23 - Prob. 30E
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following statements about T cells is false? a. Helper T cells release cytokines while cytotoxic T cells kill the infected cell. b. Helper T cells are CD4+, while cytotoxic T cells are CD8+. c. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. d. The T cell receptor is found on both CD4+ and CD8+ T cells.arrow_forwardWhich of the following statements regarding CD4 is incorrect? a. MHC class II molecules present antigens to CD4 T cells. b. CD4 is the receptor used for HIV entry into CD4 T cells. c. CD4 is made up of two separate membrane-bound chains. d. Late in the progression of an HIV infection, the number of CD4 T cells in the circulation diminishes. e. CD4 is referred to as a T-cell co-receptor.arrow_forwardAn MHC class II/antigen complex on the surface of an antigen-presenting cell (APC) binds to a T-cell receptor. What results from this interaction? Select one: a. Other immune cells are stimulated to respond to the antigen. b. Other immune cells are inhibited. c. The T cell responds by directly destroying the APC. d. The antigen is phagocytized by the T cell.arrow_forward
- The activation of a CD8-positive T lymphocyte requires presentation of antigen in association with which of the following? Class I MHC protein and synthesis of interleukin-2 by CD4 T lymphocytes. b. Class I MHC protein and synthesis of gamma-interferon by macrophages. с. Class II MHC protein and synthesis of interleukin-1 by macrophages. d. Class II MHC protein and synthesis of interleukin-4 by CD4 T lymphocytes. a.arrow_forwardWhich of the following statements regarding CD1 is correct? a. CD1 binding grooves are very similar to those of MHC class I molecules. b. Lipid antigens of CD1 bind with high affinity and are rarely exchanged. c. CD1 comprises three MHC class I-like heavy chains known as CD1c, CD1d, and CD1e, each belonging to a different functional group. d. CD1 molecules form heterodimers with β2-microglobulin. e. When a CD1d molecule presents sulfatide to a γ:δ T cell, all three CDR loops of both the γ and δ chains must be engaged to activate the T cell. f. CD1 genes are located in the HLA complex on chromosome 6.arrow_forwardThe immune system includes the various responses the body uses to ensure survival in the presence of disease-causing agents. Identify the example of innate immunity. A. Infected host cells are killed by toxic proteins from cytotoxic T cells. B. Toll-like receptors bind to foreign molecule fragments to initiate immune response. C. CD4 accessory proteins on the helper T cell surface bind to class II MHC molecules. D. IgE antibodies recognize and attach to pollen grains, stimulating an allergic reaction.arrow_forward
- A number of minor cancerous cells and infected viruses, such as Epstein Barr (EBV), are able to go undetected by cytotoxic T cell degradation by what possible mechanism? a. the production of normal class I MHC molecule b. helper T cell activation c. the deactivation of the complement system d. tumor antigen expression e. the production of the class II major histocompatability (MHC) moledulearrow_forwardIn regard to antigen presentation, MHC class I molecules usually present peptides derived from _____, whereas MHC class II molecules usually present peptides derived from _____. a. intracellular cytosolic sources; vesicular system b. phagolysosome; proteasomes c. MIIC; self proteins d. CLIP; HLA-DM e. endocytic vesicles; endoplasmic reticulum.arrow_forwardExplain why each choice (a-d) is correct or incorrect. T cells are differentiated into two groups based on their glycoproteins CD4 or CD8. Which of the following is true of CD4 T cells? a. They become cytotoxic T cells. b. The become antigen presenting cells. c. They become T helper cells. d. They become plasma cells.arrow_forward
- Which of the following statements is correct? A. CLIP binds to MHC class I molecule. B. Peptides in the ER lumen usually bind to the MHC class II peptide-binding groove. C. The invariant chain can bind to the MHC class II peptide-binding groove. D. The acidic pH trigger proteasomes to digest proteins inside endosomes. E. Calnexin, calreticulin, and tapasin associate with MHC class II molecules.arrow_forwardWhich of the following is part of the second line of defense against pathogens?a. skin b. mucus membranesc. lysozyme in tears d. phagocytes Which of the following does NOT have MHC class II molecules on the surface of their cell membranes? a. Macrophages.b. Dendritic cells.c. B cells.d. Helper T cells.arrow_forwardWhich of the following is not used as a treatment for autoimmune diseases? Select one: A. Anti-IL2 receptor B. Anti-CD4 C. Anti-MHC D. Anti-CCR5 E. Anti-T cell receptorarrow_forward
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