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Wiskott–Aldrich syndrome is an immunodeficiency disease due to mutations in the gene encoding WASp. Individuals with this disease make poor antibody responses to protein antigens, due to impaired T cell help for B cells. WASp-deficient T cells are likely impaired in providing adequate help to B cells due to: A. Defects in up-regulating expression of genes encoding cytokines required by B cells B. Defects in up-regulating metabolic pathways for T cell macromolecular synthesis C. Defects in up-regulating expression of genes needed for T cell survival D. Defects in cytoskeletal reorganization needed for directed T cell cytokine secretion E. Defects in up-regulating T cell integrin adhesion for stable interactions with B cells

Antibodies Select one: a. are not specific, but act generally. b. are composed of four light and four heavy polypeptide chains. c. play a large role in cell-mediated immunity. d. are produced by both T and B cells. e. have a variable region that binds to a specific antigenic determinant.

The MHC structure is critical for... a. Natural Killer Cells to identify healthy cells b. T cells to become activated c. B cells to get activated d. Histamines to function