EBK ORGANIC CHEMISTRY-PRINT COMPANION (
EBK ORGANIC CHEMISTRY-PRINT COMPANION (
4th Edition
ISBN: 9781119776741
Author: Klein
Publisher: WILEY CONS
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Chapter 22, Problem 67PP
Interpretation Introduction

Interpretation: For a given reaction, the expected product has to be found via reductive amination

Concept Introduction:

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride.  It reduces the carbonyl group into amine group in a rapid way.  So, it is called as reductive amination reactions.  Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

EBK ORGANIC CHEMISTRY-PRINT COMPANION (, Chapter 22, Problem 67PP , additional homework tip  1

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

EBK ORGANIC CHEMISTRY-PRINT COMPANION (, Chapter 22, Problem 67PP , additional homework tip  2

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

EBK ORGANIC CHEMISTRY-PRINT COMPANION (, Chapter 22, Problem 67PP , additional homework tip  3

To find: Plan the expected product via reductive amination using the given starting material

Draw the structures of the starting material and decide the reaction conditions

EBK ORGANIC CHEMISTRY-PRINT COMPANION (, Chapter 22, Problem 67PP , additional homework tip  4

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Chapter 22 Solutions

EBK ORGANIC CHEMISTRY-PRINT COMPANION (

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