The preparation of diazepam compound has to be proposed. Concept Introduction: Retrosynthetic analysis: In an organic synthesis , the transformation of target molecule into simpler precursor molecules regardless of any reactivity or interaction with reagents. A retrosynthetic analysis is involving the breaking of a bond to form two or more synthons.

Question

a) A favorable entropy change occurs when ΔS is positive. Does the order of the system increase or decrease when ΔS is positive? (b) A favorable enthalpy change occurs when ΔH is negative. Does the system absorb heat or give off heat when ΔH is negative? (c) Write the relation between ΔG, ΔH, and ΔS. Use the results of parts (a) and (b) to state whether ΔG must be positive or negative for a spontaneous change. For the reaction, ΔG is 59.0 kJ/mol at 298.15 K. Find the value of K for the reaction.

Answer 1

Question

Chapter 22, Problem 22.52P

(a)

Interpretation Introduction

Interpretation:

The preparation of diazepam compound has to be proposed.

Concept Introduction:

Retrosynthetic analysis:

In an organic synthesis, the transformation of target molecule into simpler precursor molecules regardless of any reactivity or interaction with reagents. A retrosynthetic analysis is involving the breaking of a bond to form two or more synthons.

(b)

Interpretation Introduction

Interpretation:

The chirality of diazepam, and the possible of number of isomers in the given synthesis has to be given.

Concept Introduction:

Stereoisomers and chiral:

Isomers differing only in their spatial arrangement of atoms are called as stereoisomers.

The geometric property of a molecule that cannot be superimposed on its mirror image is known as chirality. Chiral carbon is the one which is attached with four different groups or atoms.

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