Chapter 20, Problem 6E

(a)

Summary Introduction

To describe: The structure of the protein perilipin.

Concept introduction: Perilipin is also known as the lipid-droplet-associated protein. Perilipin belongs to a family of proteins that are associated with the surface of lipid droplets. For the mobilization of the fats in the adipose tissue, phosphorylation of perilipin is necessary. In humans, perilipin 1 is encoded by the PLIN gene.

(b)

Summary Introduction

To explain: The role of phosphorylation of perilipin to expose the lipids in the droplet to digestion by lipases.

Concept introduction: Perilipin is also known as the lipid-droplet-associated protein. Perilipin belongs to a family of proteins that are associated with the surface of lipid droplets. For the mobilization of the fats in the adipose tissue, phosphorylation of perilipin is necessary. In humans, perilipin 1 is encoded by the PLIN gene.