Interpretation:
The configuration of
Concept introduction:
With net inversion of configuration, lithium dialkylcuprates react with
A new carbon-carbon bond is formed between the alkyl group of the halide and the cuprate.
The Cahn-Ingold-Prelog rule system ranks the substituents in the chirality center in the order of decreasing
After the substituents at the chiral center is ranked with decreasing priority order, the next step is to orient the molecule so that the bond to the lowest ranked substituent points away from the observer. This is used to determine if the sequence of decreasing priority of the other three substituents is clockwise or counterclockwise. If this path is clockwise, then the configuration is
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- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning