Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 14, Problem 5CTQ
HIV predominantly infects T helper cells, cells that are responsible for coordinating B- and T-cell activity. Based upon this information, explain why HIV-infected individuals are at a very high risk for developing microbial infections.
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HIV predominantly infects T-helper cells,Based on this information, explain why HIV-infected individuals are at a very high risk for developing microbial infections
HIV predominantly infects T-helper cells, cells that are responsible for coordinating B- and T-cell activity. Based on this information, explain why HIV-infected individuals are at a very high risk for developing microbial infections. List the causative agent (virus) and discuss its properties. Name and briefly discuss 3 diseases that AIDS patients are more likely to contract.(Terminology to use: opportunistic pathogens, T and B cell purposes, CD4 cells, retrovirus, reverse transcription)
“T-lymphocytes are the most important arm of the immune response in protecting the community against virus infection.” Do you agree with this statement? Explain your reasoning in detail
Chapter 14 Solutions
Microbiology: A Systems Approach
Ch. 14.1 - Summarize the three lines of host defenses.Ch. 14.1 - Identify two components of the first line of...Ch. 14.1 - Discuss the role of normal biota as a first-line...Ch. 14.2 - Define marker, and discuss its importance in the...Ch. 14.3 - Prob. 5AYPCh. 14.3 - List the components of the mononuclear phagocyte...Ch. 14.3 - Prob. 7AYPCh. 14.3 - Prob. 8AYPCh. 14.3 - Name six types of blood cells that function in...Ch. 14.3 - Prob. 10AYP
Ch. 14.4 - List the four major categories of nonspecific...Ch. 14.4 - Summarize the steps in phagocytosis, and describe...Ch. 14.4 - Outline the steps in inflammation.Ch. 14.4 - Discuss the mechanism of fever and its role in...Ch. 14.4 - Compare and contrast the three different...Ch. 14.4 - Name three types of antimicrobial proteins.Ch. 14 - Ail example of a nonspecific chemical barrier to...Ch. 14 - Which nonspecific host defense is associated with...Ch. 14 - Prob. 3MCQCh. 14 - Which of the following is not a lymphoid tissue?...Ch. 14 - Prob. 5MCQCh. 14 - Prob. 6MCQCh. 14 - Prob. 7MCQCh. 14 - Prob. 8MCQCh. 14 - Which of the following substances is/are not...Ch. 14 - Which of the following is the end product of the...Ch. 14 - The liquid component of clotted blood is called...Ch. 14 - Prob. 12TFCh. 14 - Prob. 13TFCh. 14 - Prob. 14TFCh. 14 - Prob. 15TFCh. 14 - Prob. 1CTQCh. 14 - Prob. 2CTQCh. 14 - Prob. 3CTQCh. 14 - a. Inflammation is characterized by heat, pain,...Ch. 14 - HIV predominantly infects T helper cells, cells...Ch. 14 - Prob. 1VCCh. 14 - Prob. 1CM
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- Describe in detail what is meant by a "self- restricted/ self-tolerant" T cell. A diagram is helpful here.arrow_forwardIn HIV, helper T cells are affected. Describe how this impacts both the humoral and cell- mediated immune system. Why would an ordinary cold virus be dangerous to an AIDS patient?arrow_forwardwith HIV, explain the mechanism of intracellular infection and the role of reverse transcriptase. What would you explain about the process? What is the significance of the CD4+ count? ( Discuss the meaning of various ranges of CD4 counts.) List 5 opportunistic infections AND describe data to suggest whether or not a patient has such an infection.arrow_forward
- According to the clonal selection theory, all immunoglobulin molecules in an individual B cell have the same antigenic specificity. Explain why the presence of IgM and IgD on the same B cell does not violate the nonspecificity implied by clonal selection.arrow_forwardThe current view in the field of immunology is that dendritic cells are the primary antigen-presenting cells for stimulating naive T cells. One piece of evidence supporting this conclusion is the observation that IRF8-deficient individuals, which retain their tissue-resident macrophages, are susceptible to a range of severe opportunistic infections caused by intracellular bacteria, viruses, and fungi. Explain the reasoning behind this argument.arrow_forwardGenerally, polysaccharides are not good antigens, because B cells that recognize them cannot get T-cell help. But for some pathogens, such as Streptococcus pneumoniae opsonization by antibodies that bind the thick polysaccharide "capsule" layer surrounding the bacteria is the major mechanism of clearing the infection. As expected, a pure polysaccharide vaccine is not terribly effective, but much better immunity is achieved by vaccinating with a polysaccharide covalently linked "conjugated" to an unrelated protein. Explain how this conjugate vaccine allows B cells capable of making anti-polysaccharide antibodies.arrow_forward
- Explain the reason that T-cells are so critical in recognizing and destroying virally-infected host cells.arrow_forwardDescribe in chronological order the steps involved in the recruitment of neutrophils to infected tissue sites during an innate immune response. Use the following terms in your description: rolling adhesion, tight binding, extravasation, migration, inflammatory mediators, integrins, adhesion molecules, chemokines, selectins, sialyl-Lewisx, and basement membrane proteases.arrow_forwardCompare and contrast the production, maturation, activation and mode of action of both T Cells and B cells.arrow_forward
- Explain the process of B cell clonal selection (remember to mention the cells originated in this process with their functions).arrow_forwardTrue or False: In non-disseminated infections, Mycobacterium species are restrained by type-1 responses which increase macrophage phagocytic activity, NK and T cell activation. True or False: The low-affinity Fcε receptor (FcεRII/CD23) on mast cells will bind to IgE in tissues in the absence of antigen.arrow_forwardMacrophages and neutrophils both contribute to extracellular pathogen protection. Describe their common characteristics, differences in structure and function, and if one were eliminated from the innate immune response, explain which one would be more detrimental to the body and why.arrow_forward
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