BIOLOGY:THE ESSENTIALS (LL) W/CONNECT
3rd Edition
ISBN: 9781260670929
Author: Hoefnagels
Publisher: MCG CUSTOM
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Chapter 10, Problem 8WIO
Summary Introduction
To draw:
The mechanism of the generation of ABO genotype in red blood cells.
Introduction:
The genetic composition determines the morphology and physiology of an organism. The ABO blood group is the most clinically relevant alloantigen system. The ABO blood group involves three antigens, A, B, and H. The H antigen is converted into A or B by the activity of acetyl galactosaminyl transferase.
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Spherocytosis is an inherited blood disease in which erythrocytes (red blood cells) are spherical instead of biconcave. This condition is inherited in a dominant fashion, with ANK1 (the nonfunctional mutant allele) dominant to ANK1+. In people with spherocytosis, the spleen recognizes the spherical red blood cells as defective and removes them from the bloodstream, leading to anemia; this removal occurs with different efficiency in different people.
Some people with spherical erythrocytes suffer severe anemia, some have mild anemia, and others do not have any symptoms of anemia.
When 2400 people with the genotype ANK1/ANK1+ were examined, it was found that all of them had spherical erythrocytes, 2250 had anemia of varying severity, and 150 had no anemia symptoms. The ANK1/ANK1 genotype is never observed.
Which evidence suggests that spherocytosis is incompletely penetrant?
The gene known to be mutated in cases of Agammaglobulinemia 2 (which is inherited in an autosomal recessive pattern) is the immunoglobulin lambda like polypeptide 1 (IGLL1 ENSG00000128322). What is known about the gene is recorded here:
http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128322;r=22:23573125-23580302
Please navigate to the link above to answer the following question:
Using the left-hand menu to view the sequence for IGLL1, what are the last 12 nucleic acid bases of exon 1?
The gene known to be mutated in cases of Agammaglobulinemia 2 (which is inherited in an autosomal recessive pattern) is the immunoglobulin lambda like polypeptide 1 (IGLL1 ENSG00000128322). What is known about the gene is recorded here:
http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128322;r=22:23573125-23580302
Please navigate to the link above and click 'show transcript table' to answer the following question:
What is the NCBI accession number (including the version) of the RefSeq Match for the transcript IGLL1-202?
ANSWER: The NCBI accession number (including the version) of the RefSeq Match for the transcript IGLL1-202 is "Blank 1".
Chapter 10 Solutions
BIOLOGY:THE ESSENTIALS (LL) W/CONNECT
Ch. 10.1 - How are chromosomes, DNA, genes, and alleles...Ch. 10.1 - Prob. 2MCCh. 10.2 - Why did Gregor Mendel choose pea plants as his...Ch. 10.2 - Distinguish between dominant and recessive;...Ch. 10.3 - Prob. 1MCCh. 10.3 - How are Punnett squares helpful in following the...Ch. 10.3 - Prob. 3MCCh. 10.3 - Prob. 4MCCh. 10.4 - What is a dihybrid cross, and what is the...Ch. 10.4 - Prob. 2MC
Ch. 10.4 - Prob. 3MCCh. 10.5 - How do the patterns of inheritance differ for...Ch. 10.5 - What is the difference between recombinant and...Ch. 10.5 - Prob. 3MCCh. 10.6 - Prob. 1MCCh. 10.6 - What is pleiotropy?Ch. 10.6 - Prob. 3MCCh. 10.6 - Prob. 4MCCh. 10.7 - Prob. 1MCCh. 10.7 - Prob. 2MCCh. 10.7 - Prob. 3MCCh. 10.8 - How are pedigrees helpful in determining a...Ch. 10.8 - Prob. 2MCCh. 10.9 - Prob. 1MCCh. 10.9 - Prob. 2MCCh. 10 - In the list of four terms below, which term is the...Ch. 10 - Prob. 2MCQCh. 10 - Prob. 3MCQCh. 10 - Prob. 4MCQCh. 10 - Prob. 5MCQCh. 10 - Prob. 6MCQCh. 10 - Prob. 1WIOCh. 10 - List three genes mentioned in this chapter or not...Ch. 10 - Prob. 3WIOCh. 10 - Prob. 4WIOCh. 10 - Prob. 5WIOCh. 10 - Explain how each of the following appears to...Ch. 10 - Prob. 8WIOCh. 10 - Calico cats have large patches of orange and...Ch. 10 - Prob. 10WIOCh. 10 - Review Burning Question 10.10, which describes the...Ch. 10 - Prob. 1PITCh. 10 - Analyze the concept map and then explain the...Ch. 10 - Add meiosis, gametes, mutations, incomplete...Ch. 10 - In rose bushes, red flowers FF or Ff are dominant...Ch. 10 - In Mexican hairless dogs, a dominant allele...Ch. 10 - Prob. 3GPCh. 10 - Two lizards have green skin and large dewlaps...Ch. 10 - A fern with a genotype AA Bb Cc dd Ee mates with...Ch. 10 - In Fraggles, males are genotype XY and females are...
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- The gene known to be mutated in cases of Agammaglobulinemia 2 (which is inherited in an autosomal recessive pattern) is the immunoglobulin lambda like polypeptide 1 (IGLL1 ENSG00000128322). What is known about the gene is recorded here: http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128322;r=22:23573125-23580302 Please navigate to the link above to answer the following question: According to the web site above, how many phenotypes is IGLL1 associated with? ANSWER: IGLL1 is associated with Blank ... phenotypes.arrow_forwardThe genetic alteration responsible for sickle-cell anemia in humans involves: a transition mutation from A to G, substituting glutamic acid for valine in a-globin a transversion mutation from T to A, substituting valine for glutamic acid in b-globin a transition mutation from T to C, substituting valine for glutamic acid in b-globin a transversion mutation from G to C, substituting glutamic acid for valine in a-globin a frameshift mutation of one ATC codon, removing glutamic acid from b-globinarrow_forwardParents who both have "sickle-cell trait", i.e, are heterozygous for HbS have a child who is tested at birth, and is found to be homozygous for HbS (both alleles affected). What is the molecular reason why the child presents with no symptoms until 6 months of age? a.) the mutation affects the beta chain, which is not dominant at birth b.) the mutation affects the alpha chain, which is not dominant at birth c.) babies cannot be exposed to low oxygen that triggers symptoms d.) babies cannot be exposed to high oxygen that triggers symptomsarrow_forward
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