State whether the mutation is missense, nonsense, frameshift, or silent. B. Write the codon change that occurs for the missense, nonsense, and silent mutations (ex. GAA --  GAT). C. For frameshift mutations, write out the entire mutant sequence with each codon clearly indicated (if the frameshift creates a new stop codon, end the sequence at the new stop).     Using the wild type DNA sequence above as a guide :    Write the amino acid sequence of the mutants. Mutant 1: transition at nucleotide 23 Mutant 2: T --> G transversion at nucleotide 29 Mutant 3: an insertion of “A” after nucleotide 14

You have the following DNA coding sequence of a wild-type allele:

5’-ATG TTC CAG CTA GAT GAT ATG CTG GTA ATT GGG GAA CGC GCG CGG TAA-3’

 For each of the following mutations:

A. State whether the mutation is missense, nonsense, frameshift, or silent.

B. Write the codon change that occurs for the missense, nonsense, and silent mutations (ex. GAA --  GAT).

C. For frameshift mutations, write out the entire mutant sequence with each codon clearly indicated (if the frameshift creates a new stop codon, end the sequence at the new stop).

    Using the wild type DNA sequence above as a guide :

 Write the amino acid sequence of the mutants.

Mutant 1: transition at nucleotide 23

Mutant 2: T --> G transversion at nucleotide 29

Mutant 3: an insertion of “A” after nucleotide 14

Mutant 4: transition at nucleotide 7

Mutant 5: An insertion of GG after nucleotide 40

Mutant 6: transition at nucleotide 15

Mutant 7: a deletion of nucleotide 25