Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 10, Problem 3P
The classic demonstration that cell plasma membranes are composed of bilayers depends on the following kinds of data:
- The membrane lipids from 4.74 ×109 erythrocytes will form a monolayer of area 0.89 m2 when spread on water surface. The surface of one erythrocytes is approximately 100
- m2 in area. Show that these data can be accounted for only if the erythrocyte membrane is a bilayer.
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The classic demonstration that cell plasma membranes are composed ofbilayers depends on the following kinds of data:• The membrane lipids from 4.74 x 109 erythrocytes will form a monolayerof area 0.89 m2 when spread on a water surface.• The surface of one erythrocyte is approximately 100 μm2 in area.Show that these data can be accounted for only if the erythrocyte membraneis a bilayer.
. The classic demonstration that cell plasma membranes are composed of
bilayers depends on the following kinds of data:
• The membrane lipids from 4.74 X 1o° erythrocytes will form a mono-
layer of area 0.89 m² when spread on a water surface.
• The surface of one erythrocyte is approximately 100 um in area.
Show that these data can be accounted for only if the erythrocyte membrane
is a bilayer.
A solution containing 3.58 x 1023 molecules/m3 of protein in water is separated from pure water by a membrane 3.20 μm thick. The diffusion coefficient of the protein through the membrane is 7.15 x 10-18 m2/s. On average, how many molecules cross 0.0240 μm2 of this membrane each second? [Answer as a positive number with 3 sig digits, but do not enter units with your answer]
Chapter 10 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 10 - Prob. 1PCh. 10 - Given these molecular components--glycerol, fatty...Ch. 10 - The classic demonstration that cell plasma...Ch. 10 - The lipid portion of a typical bilayers is about...Ch. 10 - In the following situations, what is the free...Ch. 10 - Propose an experiment that would distinguish...Ch. 10 - Prob. 7PCh. 10 - Peptide hormones (such as insulin) must bind to...Ch. 10 - Prob. 9PCh. 10 - Prob. 10P
Ch. 10 - Prob. 11PCh. 10 - Prob. 12PCh. 10 - Prob. 13PCh. 10 - Prob. 14PCh. 10 - The concentration of glucose in your circulatory...Ch. 10 - ATP is synthesized from ADP, Pi , and a proton on...Ch. 10 - The Na+/ glucose symport transports glucose from...Ch. 10 - Prob. 18PCh. 10 - Prob. 19PCh. 10 - The transport of aspirin (pKa = 3.5, structure...Ch. 10 - Prob. 21P
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- The inner leaflet (monolayer) of the human erythrocyte membrane consists predominantly of phosphatidylethanolamine and phosphatidylserine. The outer leaflet consists predominantly of phosphatidylcholine and sphingomyelin. Although the phospholipid components of the membrane can diffuse in the fluid bilayer, this sidedness is preserved at all times. How?arrow_forwardPhospholipid lateral motion in membranes is characterized by a diffusion coefficient of about 1 x 10-8 cm2/sec. The distance traveled in the membrane in a given time is r = √4Dt, where r is the distance traveled in centimeters is the diffusion coefficient, and t is the time during which diffusion occurs. Calculate the distance (in nanometers) traveled by a phospholipid in a bilayer in 25 msec (milliseconds).arrow_forwardYou are developing a porous membrane for use in a dialysis system. The membrane must be able to retain both protein and glucose on the inlet side and allow other, smaller molecules to flow through. You have found that the membrane is 0.25 mm thick and contains long, rectangular pores with a width of 0.1 microns. 57% of the 50 cm^2 membrane surface area is covered with pores. A test fluid (viscosity = 1.5 cP, density = 1015 kg/m^3) is passed through the membrane. You can assume that the test fluid has a composition similar to that of blood plasma. An initial test is run at physiological conditions, and you observe that the flow rate of fluid through the membrane is 500 cm^3/min. _Given this data, what must the hydrodynamic pressure drop across the membrane in your test system be in pascals?arrow_forward
- If you made a hematocrit in two tubes. Tube A is made of 0.60M NaCl, and Tube B is made of 1.00M of NaCl, describe how the cell would respond in these solutions? Which would have a higher rate of osmosis? If the cell is permeable to NaCl, which would have a higher rate of diffusion?arrow_forwardA researcher is isolating proteins from a cell via different techniques. They find that when the cell is ground with a blender, all of the proteins in the cell can be extracted. However if instead the cell membranes are agitated in a 1.2 M KCl mixture, only about 70% of the total protein is extracted.What class of membrane proteins are in this soluble extract and what forces normally hold them to the membrane?What class of membrane proteins are the 30% of proteins that remain behind, and what forces hold these proteins in the membrane? If a solution of ionic solids was not available, what other solvent systems could be used to extract these proteins?arrow_forwardShown below are cells (colored) that were recently placed into a beaker containing a clear solution For each scenario, indicate whether movement of the molecule into the cell will occur using facilitated diffusion or active transport. А. B. 125mM 20mM fructose glucose 85MM 35mM fructose glucose OA= facilitated diffusion; B= facilitated diffusion OA= active transport; B= active transport O A= active transport; B= facilitated diffusion A= facilitated diffusion; B= active transportarrow_forward
- Use the Stokes-Einstein equation to estimate the diffusion coefficient in m2/s and in um?/s for the following particles. Assume that the particles are immersed in water in a test tube at body temperature (37 °C), which has a viscosity of approximately 0.0007 kg m1 s1. Assume the particles are all spherical Particle Diameter ATP 1.4 nm Eukaryotic ribosome 25 nm SARS-COV-2 100 nmarrow_forwardUncharged molecules can passively pass through membranes more readily than charged molecules. Acetylsalicylic acid, better known as aspirin, has a single carboxylate group with a pKa of 3.5. Approximately what percentage of the molecule is charged in the stomach, and approximately what percentage is charged at normal blood pH at the surface of a blood vessel? Finally, per unit surface area, where would the rate of passive transfer across a membrane be highest? A.) 1%, >99%, stomach B.) >99%, 1%, stomach C.) 1%, >99%, blood vessel D.) 50%, 50%, blood vessel E.)>99%, 1%, blood vessel F.) 50%, 50%, stomacharrow_forwardDiffusion experiments of a small molecule drug in tissue samples are performed. The drug has a radius of 2.24 nm and a pure-water diffusivity of 2.75 x 10^-6 cm^2/s. Cells occupy approximately 72% of the tissue byvolume. The molecule is very hydrophilic and does not readily cross cellular membranes. If you assume that the interstitial space is gel-like with a microstructure parameter k=3.7 x 10^-3 nm^-1, what is the effective diffusivity in the tissue?arrow_forward
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