Researchers have found that a certain signal transduction pathway, illustrated in the figure below, may be responsible for the development of cancer in pancreatic cells. In normal pancreatic cells, where the pathway remains inactive, a membrane-bound receptor called Ptc inhibits a downstream protein known as Smo. The inhibition of Smo blocks the activa- tion of a complex of proteins known as the HSC, which results in the cleaving of one of its proteins called Ci. The cleaving of Ci, in turn, prevents the pathway from initiating the syn- thesis of division-facilitating enzymes. Ptc B Smo с inhibition D HSC Ci cleavage A model of a Ptc signal transduction pathway under normal conditions. cell division not initiated A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and trigger uninterruptable cell division. Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell division? Hh binds to Ptc and inhibits the functioning of Ptc. cytosol Hh binds to Ptc and inhibits the activation of the HSC. Hh diffuses through the cell membrane and activates Smo Hh binds to Ptc and causes it to catalyze a reaction that uncleaves C.
Researchers have found that a certain signal transduction pathway, illustrated in the figure below, may be responsible for the development of cancer in pancreatic cells. In normal pancreatic cells, where the pathway remains inactive, a membrane-bound receptor called Ptc inhibits a downstream protein known as Smo. The inhibition of Smo blocks the activa- tion of a complex of proteins known as the HSC, which results in the cleaving of one of its proteins called Ci. The cleaving of Ci, in turn, prevents the pathway from initiating the syn- thesis of division-facilitating enzymes. Ptc B Smo с inhibition D HSC Ci cleavage A model of a Ptc signal transduction pathway under normal conditions. cell division not initiated A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and trigger uninterruptable cell division. Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell division? Hh binds to Ptc and inhibits the functioning of Ptc. cytosol Hh binds to Ptc and inhibits the activation of the HSC. Hh diffuses through the cell membrane and activates Smo Hh binds to Ptc and causes it to catalyze a reaction that uncleaves C.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Researchers have found that a certain signal transduction pathway, illustrated in the figure
below, may be responsible for the development of cancer in pancreatic cells. In normal
pancreatic cells, where the pathway remains inactive, a membrane-bound receptor called
Ptc inhibits a downstream protein known as Smo. The inhibition of Smo blocks the activa-
tion of a complex of proteins known as the HSC, which results in the cleaving of one of its
proteins called Ci. The cleaving of Ci, in turn, prevents the pathway from initiating the syn-
thesis of division-facilitating enzymes.
A
Ptc
B
Smo
с
inhibition
D
A model of a Ptc signal transduction pathway under normal conditions.
HSC
Ci cleavage
A certain protein called the Hedgehog protein (Hh) is found to activate this signal transduction pathway and
trigger uninterruptable cell division.
cell division not initiated
Which of the following describes the most plausible mechanism by which Hh triggers uninterruptable cell
division?
Hh binds to Ptc and Inhibits the functioning of Ptc.
cytosol
Hh binds to Ptc and inhibits the activation of the HSC.
Hh diffuses through the cell membrane and activates Smo
Hh binds to Ptc and causes it to catalyze a reaction that uncleaves Cl.
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